Self-Reported Pain in Children Submitted to Single Infiltration of Articaine During Primary Molar Extraction

Summary

The aim of this study is to analyze the effectiveness of articaine in controlling self-reported pain compared with conventional lidocaine anesthesia in children requiring extraction of deciduous maxillary molars. Only one extraction will be performed on each child. At least two consultations will be necessary to carry out the present controlled, randomized, and blinded study. All participants will be treated by the same dentist. Self-reported pain will be assessed using the Visual Analogue Scale.

Timeline

Start

2022-06-30

Primary completion

2024-07-04

Completion

2024-11-21

Outcome

Missed primary endpoint

paper The upper limit of the 95% CI (3.90 cm) exceeded the noninferiority margin, precluding confirmation of noninferiority (P = .919). PMID 40932429 ↗

Publications

• Background Tirupathi SP, Rajasekhar S. Can single buccal infiltration with 4% articaine induce sufficient analgesia for the extraction of primary molars in children: a systematic literature review. J Dent Anesth Pain Med. 2020 Aug;20(4):179-186. doi: 10.17245/jdapm.2020.20.4.179. Epub 2020 Aug 27.
• Background Taneja S, Singh A, Jain A. Anesthetic Effectiveness of Articaine and Lidocaine in Pediatric Patients During Dental Procedures: A Systematic Review and Meta-Analysis. Pediatr Dent. 2020 Jul 15;42(4):273-281.
• Rigo DCA, Santos PS, Moccelini BS, Rocha AO, Garcia JM, Ramos I, Santana CM, Cardoso M. Self-reported pain after buccal infiltration of articaine vs buccal and palatal infiltration of lidocaine for maxillary primary molar extractions: A noninferiority randomized clinical trial. J Am Dent Assoc. 2025 Nov;156(11):909-919. doi: 10.1016/j.adaj.2025.07.014. Epub 2025 Sep 11.

Drugs

Indications