drugset / Trial / NCT05597878
Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy
Phase 2/3
Terminated
58 enrolled
Wake Forest University Health Sciences
National Cancer Institute (NCI) · collab
RandomizedParallel-groupOpen-labelSupportive care
Summary
The objective of this study is to conduct a randomized clinical trial to evaluate an opioid versus an opioid-free pathway of perioperative use of ketamine, ketorolac, and IV acetaminophen followed by the postoperative use of ketorolac, and oral acetaminophen for pain associated with robotic-assisted radical prostatectomy. Escalation to use of opioid treatment for the opioid-free constituents will be available if needed.
Timeline
- Start
- 2023-04-18
- Primary completion
- 2026-02-26
- Completion
- 2026-02-26
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 1000 mg | Oral |
| Comparator | Ketamine | Small molecule | 1.5 mg/kg | Intravenous |
| Comparator | Ketorolac | Other / unclassified | 15 mg | Intravenous |
| Comparator | Ketorolac | Other / unclassified | 30 mg | Intravenous |
| Comparator | Oxycodone | Other / unclassified | 5 mg | Other |