drugset / Trial / NCT05693428

Influence of Anesthetics on Clinical Outcome During Cardiac Surgery in Adults

NCT05693428

Completed 90 enrolled Astana Medical University
RandomizedSequentialSingle-blindSupportive care

Summary

Abstract Cardiac surgery in adults is associated with the occurrence of post-operative complications. Even minor complications can increase the cost of their treatment. Given the potentially preventable nature of a number of these postoperative complications, preventive methods should be used to improve outcomes after cardiac surgery. One of them, is the choice of anaesthetic technique. Objectives: To evaluate the effects of sevoflurane, isoflurane and propofol on blood oxygen transport function and body energy expenditure during cardiac surgery in adults. Materials and methods. A total of 90 patients were included in the study. All patients were divided into 3 groups: 1- (n=30) included patients who were anesthetized with propofol. The second group (n=30) consisted of patients who underwent sevoflurane inhalation anaesthesia. Group 3 (n=30) was treated with isoflurane. All patients underwent coronary artery bypass grafting under cardiopulmonary bypass.

Timeline

Start
2022-01-22
Primary completion
2022-11-19
Completion
2022-11-26

Drugs

EvaluationDrugModalityDoseRoute
Subject Isoflurane Other / unclassified 1.1 unknown
Subject Isoflurane Other / unclassified 1.2 unknown
Subject Propofol Small molecule 5 mg/kg Intravenous
Subject Propofol Small molecule 6 mg/kg Intravenous
Subject Sevoflurane Other / unclassified 1.7 unknown Inhaled
Subject Sevoflurane Other / unclassified 1.9 unknown Inhaled