drugset / Trial / NCT05736549
Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2
Phase 2
Recruiting
66 enrolled
Yale University
Department of Anesthesiology Faculty Development Fund · collab
RandomizedParallel-groupSingle-blindSupportive care
Summary
The objective of this study is to investigate the efficacy of Dexamethasone sodium phosphate plus Methylprednisolone acetate in combination with plain bupivacaine ((B-DEX-MPA) compared with Liposomal Bupivacaine in combination with plain bupivacaine (B-LB) on post-surgical pain control among patients undergoing bilateral total knee arthroplasty (TKA) to asses if perineural B-DEX-MPA will result in superior analgesia efficacy as compared to B-LB. This study will also assess if perineural B-DEX-MPA results in improved quality of postoperative recovery as compared to B-LB.
Timeline
- Start
- 2023-02-07
- Primary completion
- 2027-09
- Completion
- 2028-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupivacaine | Other / unclassified | 20 ml | Other |
| Subject | Dexamethasone | Small molecule | 10 mg | Other |
| Subject | Methylprednisolone | Other / unclassified | 80 mg | Other |
| Subject | Bupivacaine | Other / unclassified | 20 ml | Other |
| Subject | Bupivacaine | Other / unclassified | 40 ml | Other |