Epinephrine Nebulization Prior to Nasotracheal Intubation

Phase 3 Completed 126 enrolled Ain Shams University

RandomizedParallel-groupSingle-blindPrevention

Summary

This randomised, prospective study performed in Ain shams university hospitals over 126 Patients ASA I and ASA II, trauma patients who suffered isolated mandibular fractures and necessitated nasal intubation during general anesthesia. The patients were randomly assigned to one of two equal groups: nasal Lidocaine drops followed by Oxymetazoline nasal drops group (OL) or Epinephrine mixed with Lidocaine as nebulization session (EL) group.

Timeline

Start: 2021-09-01
Primary completion: 2022-04-30
Completion: 2022-09-30

Publications

Background Song J. A comparison of the effects of epinephrine and xylometazoline in decreasing nasal bleeding during nasotracheal intubation. J Dent Anesth Pain Med. 2017 Dec;17(4):281-287. doi: 10.17245/jdapm.2017.17.4.281. Epub 2017 Dec 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Epinephrine	Other / unclassified	1 ml	Inhaled
Comparator	Lidocaine	Other / unclassified	2 ml	Inhaled
Comparator	Lidocaine	Other / unclassified	5 unknown	Inhaled
Comparator	Oxymetazoline	Other / unclassified	6 unknown	Intranasal

Indications

No indication recorded.