Dose Systemic Lidocaine Improve the Quality of Recovery After Colorectal Endoscopic Submucosal Dissection

Phase 4 Completed 234 enrolled Fujian Provincial Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Endoscopic submucosal dissection (ESD) is a common procedure that requires a long procedural time. Procedure Sedation is commonly provided to alleviate patients' discomfort and facilitate the implementation of procedures. We conducted a prospective study to determine the effect of intravenous infusion of lidocaine in the cognitive domain of the postoperative quality of recovery scale on day 3 after ESD.

Timeline

Start: 2023-02-24
Primary completion: 2024-03-29
Completion: 2024-04-05

Publications

Liang Y, Qian B, Zhuo Y, Zhang J, Gao W, Li H, Zhang X, Lin W. Intravenous Lidocaine and Cognitive Recovery After Endoscopic Submucosal Dissection: A Randomized Controlled Trial. Drug Des Devel Ther. 2025 Nov 22;19:10343-10355. doi: 10.2147/DDDT.S557688. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	2 mg/kg	Intravenous
Background	Propofol	Small molecule	1 mg/kg	Intravenous
Background	Sufentanil	Other / unclassified	0.1 ug/kg	—

Indications

No indication recorded.