Buffered Local Anesthetic

Summary

The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of consciousness). Two types of local anesthetic will be used--one will be buffered (by adding a salt solution to make it less acidic), while the other will be plain, without anything added. Previous studies have shown that the addition of the buffer solution can improve comfort during a dental injection.

Timeline

Start

2020-12-08

Primary completion

2023-06-12

Completion

2023-06-12

Outcome

Mixed primary results

registry analysis (superiority test); Buffered Anesthetic Side/Non-buffered Anesthetic Side; p = 0.005; Mixed Models Analysis NCT05757648 ↗

registry analysis (superiority test); Buffered Anesthetic Side/Non-buffered Anesthetic Side; p = 0.775; Mixed Models Analysis NCT05757648 ↗

registry analysis (superiority test); Buffered Anesthetic Side/Non-buffered Anesthetic Side; p = 0.682; Mixed Models Analysis NCT05757648 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Buffered Anesthetic	Unknown	8.4 %	—
Background	Epinephrine	Other / unclassified	—	—
Background	Lidocaine	Other / unclassified	2 %	—

Indications

No indication recorded.