drugset / Trial / NCT05841251
Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation
RandomizedParallel-groupTriple-blindTreatment
Summary
Coblation is a unique method of delivering radio frequency energy to the soft tissue for applications in otolaryngology. It induces reduction of the inferior turbinate by vaporizing and destroying the soft erectile tissue. The volume reduction and tissue fibrosis are immediate and sustainable. Bleeding from the vascular capillary beds of the sinonasal mucosa compromises the surgical field and increases operative time and risk of complications. In this study we try to assist hemostasis with a multifaceted approach, including use of topical vasoconstrictors "phenylephrine" and systemic antifibrinolytic agent "tranexamic acid".
Timeline
- Start
- 2023-05-01
- Primary completion
- 2023-09-01
- Completion
- 2023-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Phenylephrine | Small molecule | 0.5 % | Topical |
| Comparator | Phenylephrine | Small molecule | 5 ml | Topical |
| Comparator | Tranexamic Acid | Small molecule | 15 mg/kg | Intravenous |
Indications
No indication recorded.