drugset / Trial / NCT05861791
Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty
RandomizedParallel-groupSingle-blindSupportive care
Summary
Patients who undergoing total knee arthroplasty under spinal analgesia will be recruited and randomly assigned to the following two groups according to the regimen of PCA: (A) opioid group who receive only fentanyl citrate 1200mcg for continuous infusion drug, (B) non-opioid group who receive ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug. All the patients will receive additional fentanyl citrate as bolus injection drug if they need more analgesics postoperatively.
Timeline
- Start
- 2023-02-07
- Primary completion
- 2024-07-12
- Completion
- 2024-07-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Fentanyl | Other / unclassified | 1200 ug | Intravenous |
| Comparator | Ketorolac | Other / unclassified | 150 mg | Intravenous |
| Comparator | Nefopam | Small molecule | 100 mg | Intravenous |
Indications
No indication recorded.