Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8

Phase 0 Completed 36 enrolled Medical University of Vienna

RandomizedSingle-groupQuadruple-blindBasic science

Summary

Animal studies suggest that the transient receptor potential ion channels TRPM8 and TRPA1 are cold sensors and that sodium channels Nav1.8 and Nav1.7 are essential for detecting pain induced by cold temperatures. This study aims to validate these findings in humans.

Timeline

Start: 2023-07-07
Primary completion: 2023-09-01
Completion: 2023-09-01

Publications

Resch FJ, Heber S, Shahi F, Zauner M, Ciotu CI, Gleiss A, Sator S, Fischer MJM. Human cold pain: a randomized crossover trial. Pain. 2025 Jun 1;166(6):1406-1417. doi: 10.1097/j.pain.0000000000003503. Epub 2024 Dec 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	A-079	Small molecule	—	Other
Comparator	Lidocaine	Other / unclassified	—	Other
Subject	PF-05089771	Small molecule	—	Other
Subject	PF-05105679	Small molecule	—	Other
Subject	PF-06305591	Small molecule	—	Other

Indications

No indication recorded.