drugset / Trial / NCT06043427

Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma

NCT06043427

RandomizedParallel-groupOpen-labelTreatment

Summary

This study is being done to answer the following question: Can the chance of gastroesophageal cancer growing or spreading be lowered by adding a drug called zanidatamab to the usual combination of drugs? We are doing this study because we want to find out if this approach is better or worse than the usual approach for this type of cancer. The usual approach is defined as care most people get for gastroesophageal cancer

Timeline

Start
2024-04-16
Primary completion
2026-06-30
Completion
2026-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Zanidatamab Monoclonal antibody
Background Paclitaxel Small molecule 80 mg/m2
Background Ramucirumab Monoclonal antibody 8 mg/kg