drugset / Trial / NCT06298383
The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the desired level of anesthesia in order to deliver a pain free treatment as well as to eliminate or at least reduce post-operative pain incidence and severity. therefore, a number of pre- medications was suggested with variable success rates. Therefore this trial aims at the use of a new category of anti-inflammatory medications which would be less harmful than the standard NSAIDs or steroids.
Timeline
- Start
- 2025-06-15
- Primary completion
- 2026-02-15
- Completion
- 2026-03-15
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bromelain | Protein / enzyme biologic | 180 mg | Oral |
| Comparator | Diclofenac | Other / unclassified | 50 mg | Oral |
| Comparator | Prednisolone | Other / unclassified | 20 mg | Oral |
| Subject | Rutoside | Other / unclassified | 200 mg | Oral |
| Subject | TRYPSIN, CRYSTALLIZED | Protein / enzyme biologic | 96 mg | Oral |