drugset / Trial / NCT06345495
High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly
NaSingle-groupOpen-labelTreatment
Summary
To learn if giving ruxolitinib and busulfan before a stem cell transplant can help to reduce spleen size and help the transplant to succeed.
Timeline
- Start
- 2024-10-01
- Primary completion
- 2027-01-01
- Completion
- 2029-01-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ruxolitinib | Small molecule | — | Oral |
| Background | 2-MERCAPTOETHANESULFONIC ACID | Small molecule | — | Intravenous |
| Background | Busulfan | Small molecule | — | Intravenous |
| Background | Cyclophosphamide | Other / unclassified | — | Intravenous |
| Background | Eltrombopag | Small molecule | — | Oral |
| Background | Fludarabine | Small molecule | — | Intravenous |
| Background | Levetiracetam | Other / unclassified | — | Oral |
| Background | Romiplostim | Peptide | — | Intravenous |
| Background | Tacrolimus | Small molecule | — | Intravenous |