drugset / Trial / NCT06363877
Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
RandomizedParallel-groupSingle-blindPrevention
Summary
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.
Timeline
- Start
- 2024-06-03
- Primary completion
- 2026-10
- Completion
- 2026-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Povidone-Iodine | Other / unclassified | 500 ml | — |
| Subject | Povidone-Iodine | Other / unclassified | 1000 ml | — |
| Comparator | sodium chloride | Unknown | 500 ml | — |
| Comparator | sodium chloride | Unknown | 1000 ml | — |
| Comparator | sodium chloride | Unknown | 2000 ml | — |
Indications
No indication recorded.