drugset

drugset / Trial / NCT06477692

Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

NCT06477692 ↗

Phase 2 Recruiting 80 enrolled University of Texas Southwestern Medical Center National Cancer Institute (NCI) · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

To determine the risk of solitary elective volume recurrence following involved nodal radiotherapy (INRT) versus elective nodal irradiation (ENI)

Timeline

Start: 2024-11-14
Primary completion: 2028-07-01
Completion: 2028-07-01

Publications

Young S, Moon DH, Wang J, Chen L, Lin MH, Zhu L, Ahn C, Hughes R, Sher DJ. Involved nodal versus elective neck radiotherapy (INVERT) for head and neck squamous cell carcinoma: a prospective phase II randomized controlled trial protocol. BMC Cancer. 2026 May 11;26(1):815. doi: 10.1186/s12885-026-15904-8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Carboplatin	Small molecule	—	—
Background	Cetuximab	Monoclonal antibody	—	—
Background	Cisplatin	Other / unclassified	—	—
Background	Paclitaxel	Small molecule	—	—

Indications