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drugset / Trial / NCT06479655

Compare the Efficacy and Outcome Between Fentanyl and Morphine as Analgo-sedation in Mechanically Ventilated Patients

NCT06479655 ↗

Phase 4 Recruiting 116 enrolled Universiti Sains Malaysia
RandomizedParallel-groupOpen-labelSupportive care

Summary

The primary aim of this clinical trial is to compare the effectiveness of fentanyl vs morphine as analgosedation in mechanically ventilated adult patients in the ICU. This study also aims to compare the outcomes of patients between the two groups. The main questions it aims to answer are : 1. Does propofol and fentanyl infusion as analgo-sedation achieve targeted sedation score at 12 and 24 hours compared to propofol and morphine infusion in mechanically ventilated adult patients in the intensive care unit (ICU)? 2. Is there a difference between the proportion of patients requiring rescue sedation dose between the fentanyl and morphine groups?

Timeline

Start
2024-07-15
Primary completion
2025-11-15
Completion
2025-12-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Fentanyl Other / unclassified 0.5 ug/kg Intravenous
Comparator Fentanyl Other / unclassified 1 ug/kg Intravenous
Comparator Morphine Other / unclassified 0.05 mg/kg Intravenous
Comparator Morphine Other / unclassified 0.1 mg/kg Intravenous

Indications

No indication recorded.