Emergence Agitation Between Dexmedetomidine and Sevoflurane Anesthesia
Summary
Emergence agitation is commonly encountered after receiving inhalation anesthesia. This distressing phenomenon carries risks that are harmful to patients, caregivers and medical personnel. Using total intravenous Dexmedetomidine, the investigators seek to reduce agitation and provide gentle emergence from anesthesia.
Timeline
- Start
- 2024-07-31
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31
Outcome
Mixed primary results
registry MEAN Inhalation Sevoflurane: 3.9 (Standard Deviation 0.9) Score on a scale NCT06482125 ↗
registry MEAN Total Intravenous Dexmedetomidine: 2.5 (Standard Deviation 0.6) Score on a scale NCT06482125 ↗
registry analysis (superiority test); Inhalation Sevoflurane vs Total Intravenous Dexmedetomidine; p = 0.001; Odds Ratio (OR) 40.955 (95% CI 14.098 to 118.972) NCT06482125 ↗
registry analysis (equivalence test); Inhalation Sevoflurane vs Total Intravenous Dexmedetomidine; p = 0.345; Wilcoxon (Mann-Whitney) NCT06482125 ↗
registry analysis (equivalence test); Inhalation Sevoflurane vs Total Intravenous Dexmedetomidine; p = 0.450; Wilcoxon (Mann-Whitney) NCT06482125 ↗
Publications
- Results Liu D, Pan L, Gao Y, Liu J, Li F, Li X, Quan J, Huang C, Lian C. Efficaciousness of dexmedetomidine in children undergoing cleft lip and palate repair: a systematic review and meta-analysis. BMJ Open. 2021 Aug 16;11(8):e046798. doi: 10.1136/bmjopen-2020-046798.
- Results Peng W, Zhang T. Dexmedetomidine decreases the emergence agitation in infant patients undergoing cleft palate repair surgery after general anesthesia. BMC Anesthesiol. 2015 Oct 13;15:145. doi: 10.1186/s12871-015-0124-7.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 1.5 ug/kg | Intravenous |
| Comparator | Sevoflurane | Other / unclassified | 2 % | Inhaled |
| Comparator | Sevoflurane | Other / unclassified | 3 % | Inhaled |