drugset / Trial / NCT06494111
Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)
RandomizedSingle-groupOpen-labelSupportive care
Summary
To learn if pentoxifylline and vitamin E or pravastatin can reduce radiation-induced lymphedema/fibrosis.
Timeline
- Start
- 2025-02-13
- Primary completion
- 2029-05-01
- Completion
- 2031-03-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Pentoxifylline | Small molecule | — | Oral |
| Subject | Pravastatin | Small molecule | 40 mg | Oral |
| Subject | Vitamin E | Other / unclassified | — | Oral |