drugset
drugset / Trial / NCT06537518

The Difference Between Using Local and General Dexamethasone in Arthroscopic Anterior Cruciate Ligament Repair

NCT06537518 ↗

Completed 123 enrolled Benha University
RandomizedParallel-groupSingle-blindTreatment

Summary

Arthroscopic knee injuries, such as the anterior cruciate ligament (ACL) injury, are common and often result in postoperative pain. Regional anesthetic techniques, such as femoral nerve block (FNB) and adductor canal block (ACB), can help alleviate pain and reduce opioid consumption. ACB, which blocks the saphenous nerve and obturator nerve branches, is preferred over FNB due to its potential to decrease mobility and increase falls risk. Dexamethasone, a potent glucocorticoid, is used as an adjuvant for ACB, but its perineural administration may carry neurotoxicity risks. Some pain physicians prefer intravenous administration to prolong the action of local anesthetics used in peripheral nerve blocks.

Timeline

Start
2022-05-01
Primary completion
2022-11-20
Completion
2022-12-25

Drugs

EvaluationDrugModalityDoseRoute
Comparator Bupivacaine Other / unclassified 0.375 % Other
Comparator Bupivacaine Other / unclassified 0.5 % Other
Comparator Dexamethasone Small molecule 8 mg Other

Indications

No indication recorded.