drugset / Trial / NCT06542731
An Open-label, Uncontrolled Study of ONO-4578 and ONO-4538 in Combination With Standard-of-care Docetaxel and Ramucirumab as Second-line Therapy in Patients With Advanced or Recurrent Non-small Cell Lung Cancer
NaSingle-groupOpen-labelTreatment
Summary
This study is PhaseⅠstudy to evaluate the tolerability and safety of ONO-4578 and ONO-4538 in combination with standard-of-care docetaxel and ramucirumab as second-line therapy in patients with advanced or recurrent NSCLC who were refractory to a combination therapy containing an anti-PD-(L)1 antibody and a platinum-based drug
Timeline
- Start
- 2021-06-01
- Primary completion
- 2026-09-12
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | BMS-986310 | Small molecule | — | — |
| Subject | Nivolumab | Monoclonal antibody | — | — |
| Background | Docetaxel | Small molecule | — | — |
| Background | Ramucirumab | Monoclonal antibody | — | — |