drugset / Trial / NCT06542731

An Open-label, Uncontrolled Study of ONO-4578 and ONO-4538 in Combination With Standard-of-care Docetaxel and Ramucirumab as Second-line Therapy in Patients With Advanced or Recurrent Non-small Cell Lung Cancer

NCT06542731

Phase 1 Active not recruiting 42 enrolled Ono Pharmaceutical Co., Ltd.
NaSingle-groupOpen-labelTreatment

Summary

This study is PhaseⅠstudy to evaluate the tolerability and safety of ONO-4578 and ONO-4538 in combination with standard-of-care docetaxel and ramucirumab as second-line therapy in patients with advanced or recurrent NSCLC who were refractory to a combination therapy containing an anti-PD-(L)1 antibody and a platinum-based drug

Timeline

Start
2021-06-01
Primary completion
2026-09-12
Completion
2026-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject BMS-986310 Small molecule
Subject Nivolumab Monoclonal antibody
Background Docetaxel Small molecule
Background Ramucirumab Monoclonal antibody