drugset / Trial / NCT06558695

Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)

NCT06558695 ↗

Completed 52 enrolled University of Health Sciences
RandomizedParallel-groupDouble-blindScreening

Summary

Key Points: 1. Objective: o To compare the effects of Total Intravenous Anesthesia (TIVA) and sevoflurane anesthesia on respiratory mechanics, hemodynamic parameters, and neuromonitoring during prone position spinal surgeries. 2. Methodology: * A randomized controlled trial involving 52 patients scheduled for lumbar spine surgery, randomly assigned to either TIVA or sevoflurane groups. * Respiratory and hemodynamic parameters were measured at various time points. 3. Results: * No significant differences were found between the TIVA and sevoflurane groups in terms of respiratory mechanics or hemodynamic stability. * Both anesthesia techniques maintained stable intraoperative conditions. 4. Clinical Implications: * Anesthesiologists can flexibly choose between TIVA and sevoflurane based on patient-specific factors and surgical requirements. * TIVA may be preferred in surgeries with high neurological risk due to its compatibility with neuromonitoring. 5. Future Research: * Studies with broader patient populations and long-term outcomes are needed to further refine anesthesia management strategies. * Research on the environmental impact and cost-effectiveness of anesthesia techniques is also important.

Timeline

Start
2023-05-01
Primary completion
2023-06-30
Completion
2024-06-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Propofol Small molecule 50 ug/kg Intravenous
Comparator Propofol Small molecule 150 ug/kg Intravenous
Comparator Remifentanil Small molecule 0.02 ug/kg Intravenous
Comparator Remifentanil Small molecule 0.2 ug/kg Intravenous
Comparator Sevoflurane Other / unclassified 0.8 unknown —
Comparator Sevoflurane Other / unclassified 1 unknown —