Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)
Summary
Key Points: 1. Objective: o To compare the effects of Total Intravenous Anesthesia (TIVA) and sevoflurane anesthesia on respiratory mechanics, hemodynamic parameters, and neuromonitoring during prone position spinal surgeries. 2. Methodology: * A randomized controlled trial involving 52 patients scheduled for lumbar spine surgery, randomly assigned to either TIVA or sevoflurane groups. * Respiratory and hemodynamic parameters were measured at various time points. 3. Results: * No significant differences were found between the TIVA and sevoflurane groups in terms of respiratory mechanics or hemodynamic stability. * Both anesthesia techniques maintained stable intraoperative conditions. 4. Clinical Implications: * Anesthesiologists can flexibly choose between TIVA and sevoflurane based on patient-specific factors and surgical requirements. * TIVA may be preferred in surgeries with high neurological risk due to its compatibility with neuromonitoring. 5. Future Research: * Studies with broader patient populations and long-term outcomes are needed to further refine anesthesia management strategies. * Research on the environmental impact and cost-effectiveness of anesthesia techniques is also important.
Timeline
- Start
- 2023-05-01
- Primary completion
- 2023-06-30
- Completion
- 2024-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propofol | Small molecule | 50 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 150 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.02 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.2 ug/kg | Intravenous |
| Comparator | Sevoflurane | Other / unclassified | 0.8 unknown | — |
| Comparator | Sevoflurane | Other / unclassified | 1 unknown | — |