drugset / Trial / NCT06584227

Adebrelimab and Chidamide for Pancreatic Cancer

NCT06584227 ↗

Phase 2 Recruiting 45 enrolled Liu Xiufeng
NaSingle-groupOpen-labelTreatment

Summary

Pancreatic cancer is a kind of digestive system tumor with high malignant degree and poor prognosis. Most patients with pancreatic cancer are locally advanced or have distant metastases at the time of diagnosis, so it is extremely important to find effective drugs to control tumor metastasis. The primary treatment regimen for advanced pancreatic cancer remains chemotherapy, which results in a median survival time of only 8 to 12 months. Therefore, there is an urgent need to explore new combination therapies to extend survival. Therefore, this study aims to evaluate the efficacy and safety of Adebrelimab and Chidamide in Combination with Gemcitabine and S1 as first-line treatment for locally advanced or metastatic pancreatic cancer.

Timeline

Start
2024-09-10
Primary completion
2026-07-10
Completion
2027-05-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Adebrelimab Monoclonal antibody 1200 mg —
Subject Gemcitabine Small molecule 800 mg/m2 —
Subject Gemcitabine Small molecule 1000 mg/m2 —
Subject S-1 Small molecule 40 mg —
Subject S-1 Small molecule 50 mg —
Subject Tucidinostat Small molecule 20 mg Oral