drugset / Trial / NCT06653244
Morphine, Midazolam and Dexmedetomidine in the Management of Acute Cardiogenic Pulmonary Edema, Safety and Efficacy
RandomizedCrossoverDouble-blindTreatment
Summary
Acute cardiogenic pulmonary edema is a stressful scenario with progressive respiratory failure that may lead to cardiorespiratory collapse within hours, or minutes unless therapeutic action is taken As the initial events in involve hemodynamic pulmonary congestion with high capillary pressures, diuretics, non-invasive ventilation (NIV) and vasodilators constitute the key armamentarium for the initial treatment.
Timeline
- Start
- 2024-04-01
- Primary completion
- 2024-12-01
- Completion
- 2024-12-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | Intravenous |
| Comparator | Dexmedetomidine | Other / unclassified | 0.7 ug/kg | Intravenous |
| Comparator | Midazolam | Small molecule | 1 mg | Intravenous |
| Comparator | Morphine | Other / unclassified | 2 mg | Intravenous |
| Comparator | Morphine | Other / unclassified | 4 mg | Intravenous |
Indications
No indication recorded.