drugset / Trial / NCT06769568
Reduced-dose Conditioning Regimen Containing TBI in HSCT Treating Elderly Patients With Aplastic Anemia
NaSingle-groupOpen-labelTreatment
Summary
The TBI-containing reduced-dose conditioning regimen was used to treat elderly patients with aplastic anemia who received hematopoietic stem cell transplantation. The overall survival rate, GVHD-free survival rate, all-cause mortality,et al were studied. The modified conditioning regimen included TBI 2Gy, -7d, busulfan 3.2mg / kg-6d ; fludarabine 30mg / m2 / d-5 \~ -1d ; cyclophosphamide 25-30mg / kg / d-5 \~ -2d ; ATG ( rabbit ) 2 mg / kg / d-5 \~ -1d.
Timeline
- Start
- 2025-01-31
- Primary completion
- 2028-09-30
- Completion
- 2028-09-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Busulfan | Small molecule | 3.2 mg/kg | — |
| Subject | Cyclophosphamide | Other / unclassified | 25 mg/kg | — |
| Subject | Cyclophosphamide | Other / unclassified | 30 mg/kg | — |
| Subject | Fludarabine | Small molecule | 30 mg/m2 | — |
| Subject | Thymoglobulin | Protein / enzyme biologic | 2 mg/kg | — |