drugset / Trial / NCT06884540
Optimizing Patient-centred Outcomes Using Opioid Minimization Strategies: The OPUS Anesthesia Pilot Trial
Active not recruiting
100 enrolled
CHU de Quebec-Universite Laval
Canadian Institutes of Health Research (CIHR) · collabCanadian Perioperative Anesthesia Clinical Trials (PACT) Group · collabInternational Anesthesia Research Society (IARS) · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. The goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial to evaluate the impact of dexmedetomidine and lidocaine administered during major non-cardiac surgery on patient-centred outcomes.
Timeline
- Start
- 2025-07-15
- Primary completion
- 2027-04
- Completion
- 2027-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 0.2 ug/kg | Intravenous |
| Subject | Dexmedetomidine | Other / unclassified | 0.5 ug/kg | Intravenous |
| Subject | Dexmedetomidine | Other / unclassified | 0.7 ug/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 0.5 mg/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 1.5 mg/kg | Intravenous |
| Subject | Lidocaine | Other / unclassified | 2 mg/kg | Intravenous |