drugset / Trial / NCT06892197

Comparing Hydrocortisone and Prednisolone for Community Acquired Pneumonia (CAP)

NCT06892197

Phase 4 Recruiting 1600 enrolled Copenhagen Respiratory Research
RandomizedParallel-groupSingle-blindTreatment

Summary

The goal of this cluster randomized controlled trial is to determine the optimal treatment for community aquired pneumonia (CAP). The study compares the effects and side effects of hydrocortisone and prednisolone in patients above 18 years old diagnosed with severe CAP. The main question is whether there is a difference in all cause mortality within thirty days. Participants will be randomized to receive treatment with either hydrocortisone or prednisolone.

Timeline

Start
2026-03-10
Primary completion
2030-08-01
Completion
2030-11-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Hydrocortisone Other / unclassified 50 mg Intravenous
Comparator Hydrocortisone Other / unclassified 200 mg Intravenous
Comparator Methylprednisolone Other / unclassified 40 mg Intravenous
Comparator Prednisolone Other / unclassified 50 mg Oral

Indications