drugset / Trial / NCT06917898
Fentanyl Versus Midazolam as an Adjunct to Spinal Anesthesia
RandomizedParallel-groupDouble-blindTreatment
Summary
It is well documented in the practice of anesthesia the effectiveness of bupivacaine when added with other adjuvants including midazolam, opioids, and ketamine during neuraxial spinal block for cesarean delivery, however comparison of the superiority of midazolam 2mg over fentanyl 25 micrograms or vice versa with bupivacaine during cesarean delivery has not been established and if performed diligently, could potentially change our understanding and current practice for better patient outcomes.
Timeline
- Start
- 2025-04-01
- Primary completion
- 2026-04-30
- Completion
- 2026-04-30
Publications
- Results Khezri MB, Tahaei E, Atlasbaf AH. COMPARISON OF POSTOPERATIVE ANALGESIC EFFECT OF INTRATHECAL KETAMINE AND FENTANYL ADDED TO BUPIVACAINE IN PATIENTS UNDERGOING CESAREAN SECTION: A PROSPECTIVE RANDOMIZED DOUBLE-BLIND STUDY. Middle East J Anaesthesiol. 2016 Feb;23(4):427-36.
- Results Abdelrady MM, Fathy GM, Abdallah MAM, Ali WN. Comparison of the effect of adding midazolam versus fentanyl to intrathecal levobupivacaine in patients undergoing cesarean section: double-blind, randomized clinical trial. Braz J Anesthesiol. 2024 Jan-Feb;74(1):744385. doi: 10.1016/j.bjane.2022.06.001. Epub 2022 Jun 11.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Fentanyl | Other / unclassified | 25 ug | Intrathecal |
| Comparator | Midazolam | Small molecule | 2 mg | Intrathecal |
| Comparator | Bupivacaine | Other / unclassified | 12.5 mg | Intrathecal |
Indications
No indication recorded.