drugset / Trial / NCT06958549

Role of Nerve Block in Management of Multiple Rib Fractures

NCT06958549

Phase 4 Not yet recruiting 74 enrolled Assiut University
RandomizedParallel-groupOpen-labelTreatment

Summary

* Epidemiology \& Impact Thoracic trauma is a common and serious injury worldwide-especially in developing countries-and carries high rates of morbidity and mortality. Complications arise primarily from hypoventilation, which leads to atelectasis, pneumonia, and respiratory failure. * Key to Reducing Complications: Pain Control Effective analgesia is the cornerstone of preventing respiratory complications. Inadequate pain relief causes patients to splint and hypoventilate, setting the stage for pulmonary collapse and infection. * Conservative Management * Analgesics: Systemic pharmacological pain relief remains the mainstay. * Supportive Measures: Rest, application of ice, and encouragement of deep breathing exercises. * Incentive Spirometry: Promoted in all patients to maintain lung expansion and ward off atelectasis. * Regional Anesthesia Techniques To further improve comfort and respiratory mechanics, ultrasound-guided nerve blocks are employed according to fracture location: * Serratus Anterior Plane Block for anterolateral rib fractures * Thoracic Paravertebral Block for posterior rib fractures * Surgical Intervention Reserved for complex cases-such as flail chest or fractures with risk of organ injury-where stabilization or repair may be necessary. * Identified Gap Despite these options, thoracic surgeons currently lack a standardized, procedure-specific pain management protocol beyond systemic analgesics, highlighting a need for consensus guidelines that integrate pharmacological and regional techniques.

Timeline

Start
2025-12
Primary completion
2026-12
Completion
2027-04

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 500 mg Oral
Comparator Ketorolac Other / unclassified 15 mg Intravenous
Comparator perfelgan Unknown 1 g Intravenous

Indications

No indication recorded.