drugset / Trial / NCT07062367
Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy
RandomizedParallel-groupOpen-labelTreatment
Summary
This study will be conducted to evaluate the effects of different anesthetic modalities \[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).
Timeline
- Start
- 2025-02-01
- Primary completion
- 2027-02-01
- Completion
- 2027-02-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lidocaine | Other / unclassified | 2 mg/kg | Intravenous |
| Comparator | Propofol | Small molecule | 100 ug/kg | Intravenous |
| Comparator | Propofol | Small molecule | 250 ug/kg | Intravenous |
| Subject | Sevoflurane | Other / unclassified | — | Inhaled |
Indications
No indication recorded.