drugset
drugset / Trial / NCT07064408

Subanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients

NCT07064408 ↗

Completed 230 enrolled Hebei Medical University Fourth Hospital
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This retrospective study evaluated the effects of a subanesthetic dose of esketamine (0.25 mg/kg) on intraoperative hemodynamic stability and postoperative recovery quality in elderly patients (aged 65-75) undergoing thoracic surgery under general anesthesia. A total of 230 patients were included and randomly assigned to receive either esketamine or placebo during anesthesia induction. Key outcomes included blood pressure and heart rate stability, catecholamine levels, recovery time, incidence of adverse events such as delirium or nausea, and opioid use.

Timeline

Start
2023-06-01
Primary completion
2024-11-30
Completion
2024-11-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Esketamine Other / unclassified 0.25 mg/kg Intravenous
Background Midazolam Small molecule 2 mg Intravenous
Background Propofol Small molecule 2 mg/kg Intravenous
Background Rocuronium Other / unclassified 0.6 mg/kg Intravenous
Background Sufentanil Other / unclassified 50 ug Intravenous

Indications

No indication recorded.