drugset / Trial / NCT07069270

A Study on the First-line Treatment of Small Cell Lung Cancer With Adebrelimab and Vunakizumab and Chemotherapy

NCT07069270

Phase 2 Not yet recruiting 28 enrolled Fujian Cancer Hospital
NaSingle-groupOpen-labelTreatment

Summary

This study is a prospective, single-center, single-arm clinical trial, with a planned enrollment of 28 cases.The first Adebrelimab +Vunakizumab +EC was administered within 72 hours after enrollment for 4 to 6 cycles.At the end of the combination phase, non-PD subjects entered the maintenance treatment period of Adebrelimab plus Vunakizumab.Treatment will continue until any of the following situations occur: disease progression in the subject, intolerable toxic and side effects, comorbidiments that affect further treatment, the investigator's decision to withdraw the subject from the study, or other reasons for non-compliance with the study treatment or the study procedures or protocols.

Timeline

Start
2025-09-01
Primary completion
2026-06-01
Completion
2028-01-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Adebrelimab Monoclonal antibody 1200 mg Intravenous
Subject Carboplatin Small molecule 5 unknown
Subject Etoposide Small molecule 100 mg/m2
Subject vunakizumab Protein / enzyme biologic 240 mg Subcutaneous