drugset / Trial / NCT07102641
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
RandomizedParallel-groupOpen-labelTreatment
Summary
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.
Timeline
- Start
- 2025-08-26
- Primary completion
- 2027-08
- Completion
- 2027-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 1000 mg | — |
| Comparator | Ibuprofen | Small molecule | 600 mg | — |
| Comparator | Ketorolac | Other / unclassified | 30 mg | — |
Indications
No indication recorded.