drugset / Trial / NCT07111520

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

NCT07111520

RandomizedSequentialOpen-labelTreatment

Summary

This is a multi-site, open-label, dose-finding study, consisting of Parts 1, 2a, and 2b to investigate the combination of BNT326 with BNT327 in participants with relapsed, progressive as well as treatment-naïve, advanced/metastatic non-small cell lung cancer (NSCLC). This study will enroll adult participants with histologically or cytologically confirmed NSCLC that is advanced (i.e., either metastatic or recurrent tumors with no known curative treatment available).

Timeline

Start
2025-09-22
Primary completion
2029-01
Completion
2030-01

Drugs

EvaluationDrugModalityDoseRoute
Subject BNT326 Unknown Intravenous
Comparator Pembrolizumab Monoclonal antibody Intravenous
Subject Pumitamig Protein / enzyme biologic Intravenous
Comparator Carboplatin Small molecule Intravenous
Comparator Paclitaxel Small molecule Intravenous
Comparator Pemetrexed Small molecule Intravenous