drugset
drugset / Trial / NCT07271459

Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers

NCT07271459 ↗

Active not recruiting 40 enrolled Ain Shams University
RandomizedParallel-groupSingle-blindOther

Summary

This study aims to compare the effects of total intravenous anesthesia (TIVA) vs inhalational anesthesia on postoperative levels of inflammatory markers, length of hospital stay, and the incidence of postoperative nausea and vomiting in patients undergoing inguinal hernia repair. Number participants: Participants will be divided into 2 groups with sample size of at least 20 patients per group. Plan of the work: All patients will receive general anesthesia according to Ain Shams hospital protocol which follows the standards of the American Society of Anesthesiologists. Group A will be TIVA group and Group B will be Sevoflurane group. Sample Collection and Laboratory Analysis: Venous blood samples will be collected from each patient at three time points: preoperative (baseline, sample 0), 6 hours postoperative (sample 1), and 24 hours postoperative (sample 2).

Timeline

Start
2026-02-01
Primary completion
2026-08
Completion
2026-10

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexmedetomidine Other / unclassified 0.5 ug/kg Intravenous
Comparator Propofol Small molecule 6 mg/kg Intravenous
Comparator Propofol Small molecule 12 mg/kg Intravenous
Comparator Sevoflurane Other / unclassified 2 % Inhaled
Comparator Sevoflurane Other / unclassified 4 % Inhaled

Indications

No indication recorded.