drugset / Trial / NCT07273539
A Study to Evaluate the Effect of a Test (Sodium Bicarbonate) Toothpaste on the Oral Microbiome
RandomizedParallel-groupSingle-blindBasic science
Summary
The aim of this 12-week clinical study is to evaluate the effect of a toothpaste containing sodium bicarbonate over time on the oral microbiome and to explore its effect in comparison to a regular fluoride toothpaste in participants with localized gingivitis.
Timeline
- Start
- 2025-10-27
- Primary completion
- 2026-02-27
- Completion
- 2026-02-27
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | sodium bicarbonate | Diagnostic / imaging agent | — | Topical |
| Comparator | sodium fluoride | Unknown | 0.315 % | Topical |
| Comparator | sodium fluoride | Unknown | 1450 ppm | Topical |