The Effects of Three Different Anesthetic Methods on Postoperative Agitation

Completed 3 enrolled Inonu University

RandomizedParallel-groupDouble-blindScreening

Summary

Adult patients undergoing septoplasty surgery will be evaluated in this study. The three different anesthesia methods used will be examined for psotoperative agitation: Total intravenous anesthesia (TIVA), Combined anesthesia with sevoflurane and intravenous agents (sevoflurane-CIVIA), Balanced inhalation anesthesia with sevoflurane. Recovery patterns is extubation time, eye opening time, emergence agitation, postoperative nausea and vomiting and postoperative recovery unit discharge time.

Timeline

Start: 2025-12-25
Primary completion: 2026-02-15
Completion: 2026-04-30

Publications

Results Wolf A, Selpien H, Haberl H, Unterberg M. Does a combined intravenous-volatile anesthesia offer advantages compared to an intravenous or volatile anesthesia alone: a systematic review and meta-analysis. BMC Anesthesiol. 2021 Feb 15;21(1):52. doi: 10.1186/s12871-021-01273-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	2 ug/ml	Intravenous
Subject	Propofol	Small molecule	4 ug/ml	Intravenous
Comparator	Sevoflurane	Other / unclassified	—	Inhaled
Background	Remifentanil	Small molecule	4 ng/ml	—

Indications

No indication recorded.