drugset / Trial / NCT07352566
Utilization of a Microdevice for Psoriasis and Atopic Dermatitis
NaSingle-groupOpen-labelDevice feasibility
Summary
This study is being done to test a microdevice, which is a small device designed to test drugs directly on skin conditions like atopic dermatitis (eczema) and psoriasis. The small device, about the size of a grain of rice, has up to 20 tiny reservoirs that hold medications that are approved by the Food and Drug Administration (FDA) for atopic dermatitis and psoriasis. Very small amounts of these medications will be released into the skin (at levels in your body much lower than are typically used). In this study, the device will be tested to see if it's safe and works well for predicting how the skin will react to standard treatments. We will also look at how these reactions are connected to genetic information and overall treatment results.
Timeline
- Start
- 2026-08-01
- Primary completion
- 2030-06-01
- Completion
- 2030-06-01
Publications
- Background Tsai LL, Phillips WW, Hung YP, Dominas C, Deans K, Ahn S, Ferland B, Weiss K, Lanuti M, Auchincloss H, Schumacher L, Jonas O, Colson YL. First-in-Human Intrathoracic Implantation of Multidrug-Eluting Microdevices for In Situ Chemotherapeutic Sensitivity Testing as Proof of Concept in Nonsmall Cell Lung Cancer. Ann Surg. 2023 May 1;277(5):e1143-e1149. doi: 10.1097/SLA.0000000000005385. Epub 2023 Apr 6.
- Background Tatarova Z, Blumberg DC, Korkola JE, Heiser LM, Muschler JL, Schedin PJ, Ahn SW, Mills GB, Coussens LM, Jonas O, Gray JW. A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs. Nat Biotechnol. 2022 Dec;40(12):1823-1833. doi: 10.1038/s41587-022-01379-y. Epub 2022 Jul 4.
- Background Peruzzi P, Dominas C, Fell G, Bernstock JD, Blitz S, Mazzetti D, Zdioruk M, Dawood HY, Triggs DV, Ahn SW, Bhagavatula SK, Davidson SM, Tatarova Z, Pannell M, Truman K, Ball A, Gold MP, Pister V, Fraenkel E, Chiocca EA, Ligon KL, Wen PY, Jonas O. Intratumoral drug-releasing microdevices allow in situ high-throughput pharmaco phenotyping in patients with gliomas. Sci Transl Med. 2023 Sep 6;15(712):eadi0069. doi: 10.1126/scitranslmed.adi0069. Epub 2023 Sep 6.
- Background Jonas O, Landry HM, Fuller JE, Santini JT Jr, Baselga J, Tepper RI, Cima MJ, Langer R. An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors. Sci Transl Med. 2015 Apr 22;7(284):284ra57. doi: 10.1126/scitranslmed.3010564.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Abrocitinib | Small molecule | — | — |
| Subject | Adalimumab | Monoclonal antibody | — | — |
| Subject | Apremilast | Small molecule | — | — |
| Subject | Azathioprine | Small molecule | — | — |
| Subject | Baractinib | Unknown | — | — |
| Subject | Bimekizumab | Monoclonal antibody | — | — |
| Subject | CRAVACITINIB | Small molecule | — | — |
| Subject | Calcipotriene | Other / unclassified | — | — |
| Subject | Certolizumab | Protein / enzyme biologic | — | — |
| Subject | Chloroquine | Small molecule | — | — |
| Subject | Crisaborole | Small molecule | — | — |
| Subject | Cyclosporine | Peptide | — | — |
| Subject | Dupilumab | Monoclonal antibody | — | — |
| Subject | Etanercept | Protein / enzyme biologic | — | — |
| Subject | Guselkumab | Monoclonal antibody | — | — |
| Subject | Hydroxychloroquine | Small molecule | — | — |
| Subject | Infliximab | Monoclonal antibody | — | — |
| Subject | Ixekizumab | Monoclonal antibody | — | — |
| Subject | Lebrikizumab | Monoclonal antibody | — | — |
| Subject | Methotrexate | Small molecule | — | — |
| Subject | Mycophenolate Sodium | Unknown | — | — |
| Subject | Nemolizumab | Monoclonal antibody | — | — |
| Subject | Risankizumab | Monoclonal antibody | — | — |
| Subject | Roflumilast | Small molecule | — | — |
| Subject | Ruxolitinib | Small molecule | — | — |
| Subject | Secukinumab | Monoclonal antibody | — | — |
| Subject | Tacrolimus | Small molecule | — | — |
| Subject | Tapinarof | Other / unclassified | — | — |
| Subject | Tildrakizumab | Monoclonal antibody | — | — |
| Subject | Tofacitinib | Small molecule | — | — |
| Subject | Tralokinumab | Monoclonal antibody | — | — |
| Subject | Triamcinolone | Other / unclassified | — | — |
| Subject | Upadacitinib | Small molecule | — | — |
| Subject | Ustekinumab | Monoclonal antibody | — | — |
| Subject | fluorouracil | Small molecule | — | — |