Ultrasound Guided Lumbar Erector Spinae Block Using Bupivacaine - Magnesium Sulphate Versus Bupivacaine - Dexamethasone in Total Hip Replacement Surgery

Summary

The current study was done to evaluate the effect of adding dexamethasone and magnesium sulfate to bupivacaine as adjuvants in an ultrasound-guided erector spinae block for patients undergoing total hip arthroplasty (THA), and to assess their impact on the timing of the first request for analgesia and on overall postoperative analgesic requirements.

Timeline

Start

2025-05-01

Primary completion

2025-11-01

Completion

2025-11-25

Publications

• Results Farahata TEM, El-Bahnasawy NS, Heikal O, El-Mohaimen A. Efficacy of adding dexamethasone to levobupivacaine in erector spinae block for total hip arthroplasty. Egypt J Hosp Med. 2022;87(1):2184-2189.
• Results Reysner T, Kowalski G, Resyner M, Geisler-Wojciechowska A, Grochowicka M, et al. Erector spinae plane block for pain management after total hip arthroplasty: a systematic review and meta-analysis. Chir Narzadow Ruchu Ortop Pol. 2024;89(4):170-177.
• Results Tulgar S, Kose HC, Selvi O, Senturk O, Thomas DT, Ermis MN, Ozer Z. Comparison of Ultrasound-Guided Lumbar Erector Spinae Plane Block and Transmuscular Quadratus Lumborum Block for Postoperative Analgesia in Hip and Proximal Femur Surgery: A Prospective Randomized Feasibility Study. Anesth Essays Res. 2018 Oct-Dec;12(4):825-831. doi: 10.4103/aer.AER_142_18.
• Results Hines K, Davis E, O'Shea K, Vogl K. Rehabilitation after total hip arthroplasty. In: Essentials in Total Hip Arthroplasty. Boca Raton (FL): CRC Press; 2024. p. 269-275.
• Results Ahmed Mostafa Aref F, Abdelaziz NM, Elazazzi HM, Fahmy NG. Effect of addition of magnesium sulfate and dexamethasone versus plain bupivacaine in ultrasound-guided erector spinae plane block in pediatrics undergoing repair of inguinal hernia. Egypt J Anaesth. 2023;39(1):906-911.
• Results Abd El Rahman A, Mohamed M, Hassan A, Mohammed H. Comparative study between dexamethasone-bupivacaine versus magnesium sulfate-bupivacaine for postoperative analgesia. Sohag Med J. 2017;21(3):589-595.
• Results Desai N, Kirkham KR, Albrecht E. Local anaesthetic adjuncts for peripheral regional anaesthesia: a narrative review. Anaesthesia. 2021 Jan;76 Suppl 1:100-109. doi: 10.1111/anae.15245.
• Results Ban G, Long J, Yan K, Li Q, Huang X, Wei X, Xie F. A New Nanocomposite for Inducing Demineralized Dentin Remineralization. Int J Nanomedicine. 2025 Feb 1;20:1335-1349. doi: 10.2147/IJN.S500283. eCollection 2025.
• Results Ratnaparkhi R, Javellana M, Jewell A, Spoozak L. Evaluation of Homologous Recombination Deficiency in Ovarian Cancer. Curr Treat Options Oncol. 2024 Feb;25(2):237-260. doi: 10.1007/s11864-024-01176-6. Epub 2024 Feb 1.
• Results Zhang Y, Dong C, Zheng C, Lv Z, Tian RN, Wang M, Chen J, Wang D, Zhang X, Mao Z. Soft-in-Rigid Strategy Promoting Rapid and High-Capacity Lithium Storage by Chemical Scissoring. Inorg Chem. 2024 Jun 17;63(24):11406-11415. doi: 10.1021/acs.inorgchem.4c01493. Epub 2024 Jun 4.
• Results Ingendahl M, Vogel T, Topolinski S. The articulatory in-out effect: replicable, but inexplicable. Trends Cogn Sci. 2022 Jan;26(1):8-10. doi: 10.1016/j.tics.2021.10.008. Epub 2021 Oct 30.
• Results Wisniewska A, Czepiel K, Stachowicz A, Pomierny B, Kus K, Kiepura A, Stachyra K, Surmiak M, Madej J, Olszanecki R, Suski M. The antiatherosclerotic action of 1G244 - An inhibitor of dipeptidyl peptidases 8/9 - is mediated by the induction of macrophage death. Eur J Pharmacol. 2023 Apr 5;944:175566. doi: 10.1016/j.ejphar.2023.175566. Epub 2023 Feb 3.
• Results de la Garza CGV, Narvaez WEV, Rodriguez LDS, Fomine S. Novel 2D allotropic forms and nanoflakes of silicon, phosphorus, and germanium: a computational study. J Mol Model. 2021 Apr 28;27(5):142. doi: 10.1007/s00894-021-04775-4.
• Results Chen IY, Chang CW, Fittschen C, Luo PL. Accurate Kinetic Studies of OH + HO2 Radical-Radical Reaction through Direct Measurement of Precursor and Radical Concentrations with High-Resolution Time-Resolved Dual-Comb Spectroscopy. J Phys Chem Lett. 2024 Apr 11;15(14):3733-3739. doi: 10.1021/acs.jpclett.4c00494. Epub 2024 Mar 28.
• Results Miele E, Abballe L, Spinelli GP, Besharat ZM, Catanzaro G, Chiacchiarini M, Vacca A, Po A, Capalbo C, Ferretti E. BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors. BMC Cancer. 2020 Feb 17;20(1):129. doi: 10.1186/s12885-020-6586-0.
• Results Chan A, Ng TKT, Tang BYH. Single-Shot Lumbar Erector Spinae Plane Block in Total Hip Replacement: A Randomized Clinical Trial. Anesth Analg. 2022 Oct 1;135(4):829-836. doi: 10.1213/ANE.0000000000006162. Epub 2022 Aug 1.
• Results Chin KJ, El-Boghdadly K. Mechanisms of action of the erector spinae plane (ESP) block: a narrative review. Can J Anaesth. 2021 Mar;68(3):387-408. doi: 10.1007/s12630-020-01875-2. Epub 2021 Jan 6.
• Results Dissanayake K, Godakumara K, Fazeli A. Isolation of Extracellular Vesicles (EVs) Using Size-Exclusion High-Performance Liquid Chromatography (SE-HPLC). Methods Mol Biol. 2021;2273:189-200. doi: 10.1007/978-1-0716-1246-0_13.
• Results Roy A, Tewari B, Giri S, Goenka M. Saroglitazar in Non-alcoholic Fatty Liver Disease From Bench to Bedside: A Comprehensive Review and Sub-group Meta-Analysis. Cureus. 2023 Oct 22;15(10):e47493. doi: 10.7759/cureus.47493. eCollection 2023 Oct.
• Results Li H, Harvey DH, Dai J, Swingle SP, Compton AM, Sugali CK, Dhamodaran K, Yao J, Lin TY, Sulchek T, Kim T, Ethier CR, Mao W. Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):65. doi: 10.1167/iovs.66.2.65.
• Results Shambhavi T, Das S, Senapati LK, Padhi PP. Comparative evaluation of bupivacaine with magnesium sulphate and dexamethasone as adjuvants in ultrasound-guided transversus abdominis plane block for open unilateral inguinal hernia surgeries: A randomised controlled trial. Indian J Anaesth. 2023 Apr;67(4):370-375. doi: 10.4103/ija.ija_1091_21. Epub 2023 Apr 10.
• Results Rogge N, Janssen J. The Economic Costs of Autism Spectrum Disorder: A Literature Review. J Autism Dev Disord. 2019 Jul;49(7):2873-2900. doi: 10.1007/s10803-019-04014-z.
• Results Chin KJ, Adhikary S, Sarwani N, Forero M. The analgesic efficacy of pre-operative bilateral erector spinae plane (ESP) blocks in patients having ventral hernia repair. Anaesthesia. 2017 Apr;72(4):452-460. doi: 10.1111/anae.13814. Epub 2017 Feb 11.
• Results Husted H, Lunn TH, Troelsen A, Gaarn-Larsen L, Kristensen BB, Kehlet H. Why still in hospital after fast-track hip and knee arthroplasty? Acta Orthop. 2011 Dec;82(6):679-84. doi: 10.3109/17453674.2011.636682. Epub 2011 Nov 9.

Drugs

Indications

No indication recorded.