drugset / Trial / NCT07581704
Sirolimus Pre-conditioning on T Cell Activity and T-cell Engaging Bispecific Antibody Efficacy in Multiple Myeloma
NaSingle-groupOpen-labelTreatment
Summary
This is a single center, single arm Phase Ib study with expansion cohort designed to establish the safety and physiologic effects of sirolimus pre-conditioning followed by T-cell engaging bispecific antibody therapy.
Timeline
- Start
- 2026-06-01
- Primary completion
- 2029-06-01
- Completion
- 2029-10-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Sirolimus | Small molecule | — | — |
| Subject | Talquetamab | Monoclonal antibody | — | — |
| Subject | Teclistamab | Monoclonal antibody | — | — |