drugset / Trial / NCT07581704

Sirolimus Pre-conditioning on T Cell Activity and T-cell Engaging Bispecific Antibody Efficacy in Multiple Myeloma

NCT07581704

Phase 1 Recruiting 10 enrolled Christopher Strouse
NaSingle-groupOpen-labelTreatment

Summary

This is a single center, single arm Phase Ib study with expansion cohort designed to establish the safety and physiologic effects of sirolimus pre-conditioning followed by T-cell engaging bispecific antibody therapy.

Timeline

Start
2026-06-01
Primary completion
2029-06-01
Completion
2029-10-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Sirolimus Small molecule
Subject Talquetamab Monoclonal antibody
Subject Teclistamab Monoclonal antibody

Indications