Drugs / Talquetamab
last change Aug 2026 re-read 2 minutes ago

Talquetamab

Monoclonal antibody targets GPRC5D via depletion

Developed for
plasma cell myeloma · refractory plasma cell neoplasm · hematopoietic and lymphoid cell neoplasm · extramedullary plasmacytoma · generalized myasthenia gravis · plasma cell leukemia
Investigated by
Janssen Research & Development, LLC · Johnson & Johnson · Celgene Corporation · Janssen Pharmaceutica · Janssen Pharmaceutica N.V., Belgium · Janssen Scientific Affairs, LLC
+30 more · PETHEMA Foundation · Alfred Chung, MD · Anne Louise Tølbøll Sørensen · Blood Cancer UK · Cancer Research UK · Carl Ola Landgren, MD, PhD · Christopher Strouse · City of Hope Medical Center · Deutsche Studiengruppe Multiples Myelom (DSMM) · EMN Trial Office S.r.l. Impresa Sociale · European Myeloma Network B.V. · First Affiliated Hospital of Chongqing Medical University · HOVON - Dutch Haemato-Oncology Association · Janssen Pharmaceutical K.K. · Janssen Pharmaceuticals · Janssen Research and Development LLC · Larysa Sanchez · Massachusetts General Hospital · Medical College of Wisconsin · Memorial Sloan Kettering Cancer Center · Nantes University Hospital · National Cancer Institute (NCI) · Noffar Bar · Nordic Myeloma Study Group · North Estonia Medical Centre · SCRI Development Innovations, LLC · Stanford University · University of Arkansas · University of Heidelberg Medical Center · University of Leeds

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved · conditional EU (EMA) Talvey 2023-08-21 europa.eu

Trials 36 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT07581704 Jun 2026 → Jun 2029 expected plasma cell myeloma Christopher Strouse Recruiting No outcome recorded
Phase 1 NCT07032714 Dec 2025 → Jul 2027 expected refractory plasma cell neoplasm Massachusetts General Hospital Recruiting No outcome recorded
Phase 1 NCT07093554 Dec 2025 → Jul 2027 expected plasma cell myeloma Medical College of Wisconsin Recruiting No outcome recorded
Phase 1 NCT06348108 Jul 2025 → Jul 2027 expected plasma cell myeloma Alfred Chung, MD Recruiting No outcome recorded
Phase 1 NCT05338775 May 2022 → May 2025 overdue refractory plasma cell neoplasm Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 1 NCT05050097 Sep 2021 → Mar 2025 overdue plasma cell myeloma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 1 NCT04773522 May 2021 → Oct 2022 plasma cell myeloma Janssen Pharmaceutical K.K. Completed No outcome recorded
Phase 1 NCT04108195 Feb 2020 → Apr 2027 expected plasma cell myeloma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 1 NCT03399799 Dec 2017 → Jul 2022 overdue hematopoietic and lymphoid cell neoplasm Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06572605 Aug 2025 → Jan 2030 expected extramedullary plasmacytoma, plasma cell myeloma City of Hope Medical Center Recruiting No outcome recorded
Phase 1/2 NCT04586426 Dec 2020 → Mar 2025 overdue plasma cell myeloma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 216 trials
Phase 2 NCT07029776 Jul 2026 → Apr 2030 expected plasma cell myeloma University of Arkansas Not yet recruiting No outcome recorded
Phase 2 NCT07107529 Dec 2025 → Apr 2029 expected plasma cell myeloma European Myeloma Network B.V. Recruiting No outcome recorded
Phase 2 NCT06827860 Nov 2025 → Jan 2027 expected plasma cell myeloma Larysa Sanchez Recruiting No outcome recorded
Phase 2 NCT06993675 Aug 2025 → Aug 2029 expected plasma cell myeloma Noffar Bar Recruiting No outcome recorded
Phase 2 NCT06461988 Jun 2025 → Dec 2027 expected disease related to hematopoietic stem cell transplant, plasma cell myeloma Stanford University Recruiting No outcome recorded
Phase 2 NCT06550895 Sep 2024 → Aug 2027 expected plasma cell myeloma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 2 NCT06500884 Aug 2024 → May 2030 expected plasma cell myeloma Janssen Research & Development, LLC Recruiting No outcome recorded
Phase 2 NCT06577025 Aug 2024 → Sep 2030 expected plasma cell myeloma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 2 NCT06353022 Jun 2024 → Apr 2028 expected plasma cell myeloma Nantes University Hospital Active not recruiting No outcome recorded
Phase 2 NCT06505369 Jun 2024 → Nov 2026 expected plasma cell myeloma North Estonia Medical Centre Recruiting No outcome recorded
Phase 35 trials
Phase 3 NCT07649525 Jul 2026 → Jun 2033 expected plasma cell leukemia, plasma cell myeloma University of Leeds Recruiting No outcome recorded
Phase 3 NCT06208150 Jan 2024 → Apr 2026 overdue plasma cell myeloma Janssen Research & Development, LLC Recruiting No outcome recorded
Phase 3 NCT05552222 Oct 2022 → Apr 2031 expected plasma cell myeloma Janssen Research & Development, LLC Recruiting No outcome recorded
Phase 3 NCT05461209 Oct → Nov 2022 refractory plasma cell neoplasm Janssen Research & Development, LLC Withdrawn No outcome recorded
Phase 3 NCT05455320 Oct 2022 → Jul 2027 expected plasma cell myeloma Janssen Research & Development, LLC Active not recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT07474961 Mar 2027 → Dec 2036 expected Waldenstrom macroglobulinemia, plasma cell myeloma Anne Louise Tølbøll Sørensen Not yet recruiting No outcome recorded
Phase not applicable1 trial
NCT07499323 Mar 2026 → Mar 2027 expected generalized myasthenia gravis First Affiliated Hospital of Chongqing Medical University Not yet recruiting No outcome recorded
Phase not stated2 trials
NCT05757973 refractory plasma cell neoplasm Janssen Research & Development, LLC Approved for marketing No outcome recorded
NCT05503550 refractory plasma cell neoplasm Janssen Research & Development, LLC No longer available No outcome recorded
Also used as a comparator or background therapy in 2 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT07657312 Background Aug 2026 → Dec 2027 expected cytokine release syndrome, plasma cell myeloma Naresh Bumma Recruiting No outcome recorded
Phase 2 NCT03601078 Background Dec 2018 → Jan 2026 plasma cell myeloma Celgene Corporation Completed No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 41 sources stand behind the page.

FieldValueCited text
Known as Talquetamab Talquetamab is a bispecific antibody that binds the CD3 receptor on T-cells and the GPRC5d receptor on multiple myeloma cells.” NCT07581704
37

NCT06461988

NCT05338775

NCT06827860

NCT04586426

NCT07093554

NCT06208150

NCT05972135

NCT06348108

NCT06066346

NCT05050097

NCT03601078

NCT03399799

NCT05552222

NCT07649525

NCT07657312

NCT06572605

NCT06100237

NCT07107529

NCT05849610

NCT05503550

NCT04108195

NCT06500884

NCT07032714

NCT07474961

NCT06577025

NCT04773522

NCT04634552

NCT05757973

NCT06550895

NCT06993675

NCT06353022

NCT05455320

NCT05695508

NCT05461209

NCT07499323

NCT07029776

NCT06505369

Known as JNJ-63483043 ChEMBL registry synonym — accepted as the source's own label CHEMBL4594503
Known as JNJ-64407564 “Talquetamab (JNJ-64407564) and Lenalidomide as Post Stem Cell Transplant Maintenance in Multiple Myeloma (OPTIMMAL)” NCT06461988
Known as Talquetamab-tgvs ChEMBL registry synonym — accepted as the source's own label CHEMBL4594503
Known as Talvey ChEMBL registry synonym — accepted as the source's own label CHEMBL4594503
Action Activate “Talquetamab (anti-G protein-coupled receptor family C group 5 member D) and teclistamab (anti-B-cell maturation antigen) are bispecific antibodies that activate T cells by targeting CD3” PMID 39778168 Jan 2025
Modality Monoclonal antibody “Talquetamab, a bispecific antibody against CD3 and GPRC5D” PMID 36507686 Dec 2022
Route Intravenous “Participants will receive IV infusion or SC injection of Talquetamab.” NCT03399799
Route Subcutaneous “Participants will receive IV infusion or SC injection of Talquetamab.” NCT03399799
Target GPRC5D “Talquetamab, a bispecific antibody against CD3 and GPRC5DPMID 36507686 Dec 2022