drugset / Trial / NCT07679828
Polypills Approach for Multiple Cardiovascular Risk Factors
RandomizedParallel-groupSingle-blindTreatment
Summary
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for integrated management of hypertension, dyslipidemia, and diabetes among adults aged 50 to 75 years in China. The trial will evaluate whether a simplified regimen combining blood pressure-lowering, lipid-lowering, and glucose-lowering therapy improves the 10-year cardiovascular disease risk score at phase 1. Participants will be followed to determine whether the fixed-dose combination strategy reduces major cardiovascular events and cognitive function compared with usual care at phase 2.
Timeline
- Start
- 2026-07-01
- Primary completion
- 2029-12-31
- Completion
- 2030-03-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amlodipine | Other / unclassified | 2.5 mg | — |
| Subject | Amlodipine | Other / unclassified | 5 mg | — |
| Subject | Dapagliflozin | Small molecule | 10 mg | — |
| Subject | Ezetimibe | Unknown | 10 mg | — |
| Subject | Indapamide | Small molecule | 2.5 mg | — |
| Subject | Olmesartan medoxomil | Unknown | 10 mg | — |
| Subject | Olmesartan medoxomil | Unknown | 20 mg | — |
| Subject | Rosuvastatin | Small molecule | 5 mg | — |
| Subject | Rosuvastatin | Small molecule | 10 mg | — |