drugset
drugset / Trial / NCT07801157

Topical Phenytoin-Loaded Hydrogel Dressing for Postoperative Wound Management After Oral Squamous Cell Carcinoma Resection

NCT07801157 ↗

Completed 24 enrolled Mansoura University
RandomizedParallel-groupSingle-blindSupportive care

Summary

This randomized, parallel-arm clinical trial evaluated whether a topical phenytoin-loaded hydrogel dressing could improve postoperative wound healing in patients undergoing surgical resection and reconstruction for locally advanced oral squamous cell carcinoma. Twenty-four participants were randomized in a 1:1 ratio to conventional postoperative wound care alone or to the same conventional care plus topical phenytoin-loaded hydrogel. The primary outcome was postoperative wound healing assessed using the Pippi modification of the Landry Wound Healing Index. Secondary outcomes were postoperative complications, oral mucositis severity, postoperative pain, and length of hospital stay. Follow-up in the revised manuscript extends through six months after surgery.

Timeline

Start
2024-07-01
Primary completion
2025-12-01
Completion
2025-12-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Phenytoin Unknown 10 % Topical
Background Bacitracin Unknown — Topical
Background Benzydamine Unknown — Oral
Background Chlorhexidine Small molecule — Oral
Background Neomycin Unknown — Topical
Background Povidone-Iodine Other / unclassified 10 % Topical

Indications

No indication recorded.