drugset / Trial / NCT07831902
Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features (RAINBO) - NSMP-ORANGE Trial: Comparing Radiotherapy With Oral Progestin Tablets vs. the Current Standard Care, Radiotherapy and Chemotherapy, in Patients With NSMP Endometrial Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
RAINBO NSMP-ORANGE aims to investigate if adjuvant radiotherapy with oral progestin tablets is as effective as radiotherapy with chemotherapy, whilst reducing toxicity and thus improving quality of life, in patients with high-risk NSMP endometrial cancer. Patients will be randomised to radiotherapy with chemotherapy (standard of care), or radiotherapy followed by oral progestin tablets.
Timeline
- Start
- 2026-06-29
- Primary completion
- 2030-12
- Completion
- 2034-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Carboplatin | Small molecule | — | — |
| Comparator | Cisplatin | Other / unclassified | — | — |
| Subject | Megestrol Acetate | Other / unclassified | 160 mg | Oral |
| Comparator | Paclitaxel | Small molecule | — | — |
| Subject | medroxyprogesterone acetate | Other / unclassified | 200 mg | Oral |