Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart Surgery
Summary
This study compared two opioid pain medications - morphine and fentanyl - used during open-heart surgery in young children born with heart defects (congenital heart disease). During open-heart surgery, the heart is temporarily stopped to allow surgeons to repair the defect. This process can cause damage to the heart muscle due to reduced blood flow and its restoration, known as ischemia-reperfusion injury, which is one of the leading causes of complications in children undergoing heart surgery. Morphine is known to activate specific receptors in the heart that may help protect it against this type of injury - a process called pharmacological preconditioning. While fentanyl has largely replaced morphine in pediatric cardiac anesthesia over the years, emerging evidence suggests that morphine may have unique heart-protective properties that fentanyl lacks. The purpose of this study was to investigate whether morphine provides better heart muscle protection than fentanyl in children with non-cyanotic congenital heart disease undergoing elective open-heart surgery. The study also aimed to compare postoperative recovery, need for heart-supporting medications, and other clinical outcomes between the two groups.
Timeline
- Start
- 2022-09-02
- Primary completion
- 2023-09-20
- Completion
- 2023-09-20
Publications
- Background Zhang R, Shen L, Xie Y, Gen L, Li X, Ji Q. Effect of morphine-induced postconditioning in corrections of tetralogy of fallot. J Cardiothorac Surg. 2013 Apr 11;8:76. doi: 10.1186/1749-8090-8-76.
- Background Murphy GS, Szokol JW, Marymont JH, Greenberg SB, Avram MJ, Vender JS, Sherwani SS, Nisman M, Doroski V. Morphine-based cardiac anesthesia provides superior early recovery compared with fentanyl in elective cardiac surgery patients. Anesth Analg. 2009 Aug;109(2):311-9. doi: 10.1213/ane.0b013e3181a90adc.
- Background Groban L, Butterworth J. Fentanyl: destiny or devil? Anesth Analg. 2009 Aug;109(2):301-2. doi: 10.1213/ane.0b013e3181a91944. No abstract available.