Drugs / Testosterone Cypionate
last change Aug 2026 re-read 2 minutes ago

Testosterone Cypionate

Small molecule targets AR via activation

Developed for
castration-resistant prostate carcinoma · prostate cancer · hypogonadism, male · prostate adenocarcinoma · prostate carcinoma · Klinefelter syndrome · metastatic prostate carcinoma · critical illness polyneuropathy
+5 more · hematologic disorder · hypogonadism · myopathy · female stress incontinence · metabolic bone disorder
Investigated by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · National Cancer Institute (NCI) · Bayer · United States Department of Defense · Prostate Cancer Foundation · University of Colorado, Denver
+28 more · University of Washington · AstraZeneca · Azurity Pharmaceuticals · Baylor College of Medicine · Brigham and Women's Hospital · Bristol-Myers Squibb · CBCC Global Research · Dendreon · Emory University · Enhanced Emirates Limited · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · H. Lee Moffitt Cancer Center and Research Institute · Hospital Moinhos de Vento · Hospital Sirio-Libanes · Hospital de Clinicas de Porto Alegre · Latin American Cooperative Oncology Group · Leticia Maria Defendi Barboza Marson · National Institutes of Health (NIH) · Panbela Therapeutics, Inc. · Parc de Salut Mar · Roswell Park Cancer Institute · São Paulo Research Foundation · University of California, San Diego · University of Miami · University of Sao Paulo · VA Office of Research and Development · Yale University · Zenith Epigenetics

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) TESTOSTERONE CYPIONATE 1978-06-23 fda.gov

Trials 29 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT06305598 Dec 2024 → Dec 2029 expected castration-resistant prostate carcinoma, metastatic prostate carcinoma Roswell Park Cancer Institute Recruiting No outcome recorded
Phase 1 NCT04731376 Jan 2021 → Nov 2024 overdue hypogonadism, male, malignant urinary system neoplasm Emory University Active not recruiting No outcome recorded
Phase 1 NCT04757532 Dec 2020 → Mar 2021 Parc de Salut Mar Completed No outcome recorded
Phase 1 NCT01378299 Oct 2011 → Nov 2016 hypogonadism, male VA Office of Research and Development Completed No outcome recorded
Phase 216 trials
Phase 2 NCT07142551 Mar 2026 → Jun 2030 expected castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT07476001 Mar 2026 → Sep 2027 expected prostate carcinoma H. Lee Moffitt Cancer Center and Research Institute Recruiting No outcome recorded
Phase 2 NCT06922318 Aug 2025 → Aug 2031 expected castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT06039371 May 2024 → Mar 2027 expected castration-resistant prostate carcinoma, prostate adenocarcinoma University of Washington Recruiting No outcome recorded
Phase 2 NCT06100705 Dec 2023 → Dec 2027 expected prostate carcinoma Yale University Recruiting No outcome recorded
Phase 2 NCT06059118 Oct 2023 → Jan 2027 expected prostate cancer Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT04895306 Nov 2022 → Mar 2026 hypogonadism, substance-related disorder Brigham and Women's Hospital Completed No outcome recorded
Phase 2 NCT04704505 Apr 2022 → Feb 2028 expected castration-resistant prostate carcinoma, prostate adenocarcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT04558866 Jun 2021 → Mar 2024 overdue prostate cancer Latin American Cooperative Oncology Group Active not recruiting No outcome recorded
Phase 2 NCT04424654 Sep 2020 → May 2022 prostate cancer Hospital Sirio-Libanes Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03038919 Oct 2016 → Oct 2017 critical illness polyneuropathy Hospital de Clinicas de Porto Alegre Unknown No outcome recorded
Phase 46 trials
Phase 4 NCT07278362 May 2026 → May 2031 expected hypogonadism, male, prostate cancer University of Miami Not yet recruiting No outcome recorded
Phase 4 NCT07328542 Feb 2026 → Jun 2027 expected hypogonadism, male Azurity Pharmaceuticals Not yet recruiting No outcome recorded
Phase 4 NCT06592144 Sep 2024 → Aug 2026 overdue myopathy Leticia Maria Defendi Barboza Marson Active not recruiting No outcome recorded
Phase 4 NCT04321551 Jul 2023 → Jun 2028 University of California, San Diego Withdrawn No outcome recorded
Phase 4 NCT03325647 Nov 2017 → May 2021 Klinefelter syndrome University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT02408445 May 2015 → Jan 2018 Klinefelter syndrome University of Colorado, Denver Completed No outcome recorded
Phase not applicable2 trials
NCT07568574 Mar 2026 → May 2028 expected Enhanced Emirates Limited Enrolling by invitation No outcome recorded
NCT05487794 Sep 2022 → Nov 2024 hematologic disorder University of Sao Paulo Completed No outcome recorded
Also used as a comparator or background therapy in 7 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT02995330 Background Feb 2017 → Jun 2021 prostate cancer Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Terminated No outcome recorded
Phase 23 trials
Phase 2 NCT06111209 Comparator Feb 2025 → Dec 2026 expected female stress incontinence Brigham and Women's Hospital Active not recruiting No outcome recorded
Phase 2 NCT03716739 Comparator Mar 2019 → May 2025 prostate cancer Dana-Farber Cancer Institute Completed No outcome recorded
Phase 2 NCT00853502 Comparator Dec 2008 → Oct 2016 metabolic bone disorder Massachusetts General Hospital Withdrawn No outcome recorded
Phase 43 trials
Phase 4 NCT07092527 Comparator Dec 2025 → Nov 2028 expected reproductive system disorder University of California, San Diego Recruiting No outcome recorded
Phase 4 NCT06450405 Comparator Feb 2025 reproductive system disorder University of California, San Diego Terminated No outcome recorded
Phase 4 NCT04439799 Comparator Aug 2020 → Feb 2023 hypogonadism, male University of Miami Completed No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 37 sources stand behind the page.

FieldValueCited text
Known as Testosterone Cypionate “Depo-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic...” NCT04321551
34

“All Patients will receiveTestosterone Cypionate 400mg IM every 28 days, until progression or unacceptable toxicity.” NCT04704505

NCT06039371

NCT06922318

NCT06100705

NCT03716739

NCT01378299

NCT03554317

NCT06592144

NCT04363164

NCT04895306

NCT07092527

NCT06450405

NCT02995330

NCT02090114

NCT07278362

NCT02408445

NCT04439799

NCT03325647

NCT02286921

NCT07476001

NCT03038919

NCT07142551

NCT06059118

NCT01750398

NCT04558866

NCT03516812

NCT07328542

NCT06111209

NCT04731376

NCT06305598

NCT04424654

NCT00853502

NCT07568574

NCT05487794

Known as Andro-cyp ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as Azmiro ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as DEPO-Testosterone DEPO-TestosteroneNCT06100705
Known as Depo-Testosterone Injection DEPo-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic...” NCT01378299
1

Depo-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble of the androgenic hormone testosterone.” NCT04363164

Known as Depotest ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as NSC-9157 ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as Testosterone 17.beta.-cyclopentanepropionate ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as Testosterone cipionate ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as Testosterone cyclopentylpropionate ClinicalTrials.gov intervention name — accepted as the source's own label NCT04757532
Known as Testosterone cypionate ciii ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Known as Testosterone cypionate component of depo-testadiol ChEMBL registry synonym — accepted as the source's own label CHEMBL1201101
Action Activate “Androgen Receptor agonist” CHEMBL1201101
Modality Small molecule CHEMBL1201101
Route Intramuscular “dose dependent on pubertal stage, intramuscular injection once every 3 weeks for 12 months” NCT00853502
Target AR “Androgen Receptor agonist” CHEMBL1201101