Drugs / Saccharomyces boulardii
last change Dec 2025 re-read 2 minutes ago

Saccharomyces boulardii

Other / unclassified

Developed for
Helicobacter pylori infectious disease · irritable bowel syndrome · cirrhosis of liver · acute diarrhea · asthma · atopic eczema · chronic periodontitis · diarrheal disease
+8 more · heart failure · necrotizing enterocolitis · obesity disorder · urinary tract infection · Clostridium difficile colitis · gastroenteritis · small intestinal bacterial overgrowth · systolic heart failure
Investigated by
Biocodex · Aga Khan University · Anlu Puai Hospital · Ann & Robert H Lurie Children's Hospital of Chicago · Azienda di Servizi alla Persona di Pavia · B.P. Koirala Institute of Health Sciences
+23 more · Central Hospital of Xiaogan · Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno · Clinical Centre of Serbia · Daewoong Pharmaceutical Co. LTD. · Faculty of Medicine, University of Indonesia · Federal University of Minas Gerais · Fluminense Federal University · Huazhong University of Science and Technology · Hubei Aerospace Hospital · I.M. Sechenov First Moscow State Medical University · Jae Myung Park · King Edward Medical University · Kyunghee University Medical Center · Nepal Health Research Council · RESnTEC, Institute of Research · Tatyasaheb Kore Dental College · The Third People's Hospital of Hubei Province · The Third Xiangya Hospital of Central South University · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan University · Xiaogan First People's Hospital · Zekai Tahir Burak Women's Health Research and Education Hospital · Zhongda Hospital

Trials 20 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT06149676 Feb 2022 → Dec 2024 urinary tract infection Ann & Robert H Lurie Children's Hospital of Chicago Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT03516370 Nov 2017 → Mar 2018 chronic periodontitis Tatyasaheb Kore Dental College Completed No outcome recorded
Phase 24 trials
Phase 2 NCT05993247 Aug 2023 → Aug 2025 osteoarthritis Jae Myung Park Unknown No outcome recorded
Phase 2 NCT01762748 Jan 2011 → Dec 2012 cirrhosis of liver Federal University of Minas Gerais Completed No outcome recorded
Phase 2 NCT01500343 Nov 2008 → Mar 2010 heart failure Fluminense Federal University Completed No outcome recorded
Phase 2 NCT00002088 HIV infectious disease, diarrheal disease Biocodex Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT06657066 Dec 2021 → Apr 2022 asthma King Edward Medical University Completed No outcome recorded
Phase 32 trials
Phase 3 NCT01315821 Feb → Dec 2011 necrotizing enterocolitis Zekai Tahir Burak Women's Health Research and Education Hospital Unknown No outcome recorded
Phase 3 NCT00589771 Jan 2010 → Dec 2011 irritable bowel syndrome Aga Khan University Completed No outcome recorded
Phase 43 trials
Phase 4 NCT03997279 Jun 2019 → Jun 2020 Helicobacter pylori infectious disease Clinical Centre of Serbia Unknown No outcome recorded
Phase 4 NCT04627337 Feb 2017 → Jul 2018 irritable bowel syndrome Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno Completed No outcome recorded
Phase 4 NCT03220542 Jan 2016 → Dec 2018 Helicobacter pylori infectious disease Kyunghee University Medical Center Unknown No outcome recorded
Phase not applicable8 trials
NCT07012785 Jun → Dec 2025 overdue Helicobacter pylori infectious disease Zhongda Hospital Not yet recruiting No outcome recorded
NCT06540209 Apr → Sep 2023 acute diarrhea RESnTEC, Institute of Research Completed No outcome recorded
NCT05451433 Aug 2022 irritable bowel syndrome Faculty of Medicine, University of Indonesia Unknown No outcome recorded
NCT05191875 Dec 2021 → Apr 2022 Helicobacter pylori infectious disease The Third Xiangya Hospital of Central South University Completed No outcome recorded
NCT05231772 Mar 2021 → Mar 2022 cirrhosis of liver I.M. Sechenov First Moscow State Medical University Completed No outcome recorded
NCT04706559 Jan → Sep 2021 atopic eczema B.P. Koirala Institute of Health Sciences Completed No outcome recorded
NCT03688828 Nov 2018 → Jun 2020 Helicobacter pylori infectious disease Huazhong University of Science and Technology Completed No outcome recorded
NCT04919850 Jan 2018 obesity disorder Azienda di Servizi alla Persona di Pavia Completed No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT02637167 Comparator Mar 2016 → Jun 2019 systolic heart failure Oslo University Hospital Unknown No outcome recorded
Phase 31 trial
Phase 3 NCT01143272 Comparator Jun 2010 → Oct 2012 Clostridium difficile colitis, diarrheal disease Bernhard Nocht Institute for Tropical Medicine Terminated No outcome recorded
Phase 44 trials
Phase 4 NCT03539913 Comparator Jun 2017 → Jun 2018 gastroenteritis Biocodex Completed No outcome recorded
Phase 4 NCT03692299 Comparator Jun 2015 → Jul 2019 small intestinal bacterial overgrowth, systemic sclerosis Coordinación de Investigación en Salud, Mexico Completed No outcome recorded
Phase 4 NCT00807326 Comparator Nov 2008 → Aug 2009 diarrheal disease McNeil AB Completed No outcome recorded
Phase 4 NCT00543478 Comparator Oct 2007 → Jul 2008 irritable bowel syndrome Aga Khan University Unknown No outcome recorded

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 30 sources stand behind the page.

FieldValueCited text
Known as saccharomyces boulardii Saccharomyces Boulardii Combined With Quadruple Therapy for Helicobacter pylori Eradication Decreased the Duration and Severity of Diarrhea: A Multi-Center Prospective...” PMID 34869495 Nov 2021
27

“Probiotics combination capsule (Bacillus Subtilis 150 mg /Clostridium Burtyricum Toa 150 mg /Saccharomyces Boulardii 113 mg) per oral, three times a day, for 8 weeks” NCT05993247

“To evaluate the efficacy of locally delivered saccharomyces boulardii on clinical and microbiological parameters in the treatment of chronic periodontitis.” NCT03516370

“A complex of 250 mg of Saccharomyces boulardii and 500 IU SOD to be assumed twice/day for 8 weeks at mealtimes” NCT04919850

Saccharomyces boulardii + Esomeprazole + Amoxicillin + Clarithromycin” NCT03220542

“Drug: Saccharomyces boulardiiNCT03997279

NCT01762748

NCT06540209

NCT02637167

NCT04706559

NCT03539913

NCT01143272

NCT00002088

NCT00589771

NCT07012785

NCT03692299

NCT05191875

NCT00543478

NCT03516370

NCT04627337

NCT06149676

NCT01500343

NCT03688828

NCT05231772

NCT01315821

NCT00807326

NCT05451433

NCT06657066

Known as CNCM I-745 “Our aim was to compare the efficacy and safety of 2 probiotics (Saccharomyces boulardii CNCM I-745 vs a 4-strain mixture of Bacillus clausii O/C, SIN, N/R, T) for the treatment of PAGE.” PMID 36086703 Sep 2022
Known as Florastor “Saccharomyces Boulardii 250 MG [Florastor]” NCT06149676
Known as S. boulardii “CONCLUSIONS: Metronidazole treatment is partially effective in SIBO, but S. boulardii in monotherapy or in combination improves the gastrointestinal outcomes in SSc.” PMID 31549334 Sep 2019
1

“or S. boulardii (250 mg twice daily for 5 days)” PMID 26541878 Dec 2015

Known as Sac. boulardii “The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD.” NCT01143272
Known as Saccharomyces boulardii CNCM I-745 Saccharomyces boulardii CNCM I-745 is a probiotic yeast that has proven efficacy for the treatment of acute gastroenteritis and antibiotic-associated diarrhea.” NCT04627337
Known as Saccharomyces cerevisiae var. boulardii “The non-pathogenic yeast Saccharomyces cerevisiae var. boulardii (Sac. boulardii) is considered the most promising probiotic substance for the prevention of AAD and CDAD.” NCT01143272
Known as Sacchraomyces Boulardii “Effect Of A Locally Delivered Probiotic Sacchraomyces Boulardii In The Management Of Chronic Periodontitis” NCT03516370
Modality Other / unclassified “Saccharomyces Boulardii is a probiotic yeast” NCT00543478
Route Oral Oral, 1 capsule twice a day, maximum 2 capsules in a 24 hour period for a maximum of 5 days” NCT00807326