Drugs / Methacholine
Methacholine
also known as
Methacholine Chloride · SK-1211 · Chlorure de methacholine · Cloruro de metacolina · Mecholyl bromide · METHACHOLINE BROMIDE · Methacholine cation · Methacholine ion · +2 more
Diagnostic / imaging agent targets CHRM3 via activation
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | PROVOCHOLINE | — | 2019-11-08 | fda.gov ↗ |
| Approved | US (FDA) | PROVOCHOLINE | — | 1986-10-31 | fda.gov ↗ |
Trials 10 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 34 trials | ||||||
| Phase 3 | NCT03505489 | Jun 2018 → Apr 2019 | asthma | University of Saskatchewan | Completed | No outcome recorded |
| Phase 3 | NCT02100267 | Apr → Sep 2014 | asthma | Sanwa Kagaku Kenkyusho Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT02097537 | Feb → Jul 2014 | asthma | Santen Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT00252291 | Nov 2005 → Sep 2006 | asthma | Syntara | Completed | No outcome recorded |
| Phase not applicable6 trials | ||||||
| — | NCT05634473 | Dec 2022 → Feb 2023 | asthma | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Unknown | No outcome recorded |
| — | NCT02630511 | Dec 2015 → Dec 2020 | asthma | University of Alberta | Completed | No outcome recorded |
| — | NCT03062904 | Feb 2014 → Dec 2019 | — | Assistance Publique - Hôpitaux de Paris | Unknown | No outcome recorded |
| — | NCT01547286 | May 2012 → Oct 2013 | asthma, atopic IgE-mediated allergic disorder | Massachusetts General Hospital | Completed | No outcome recorded |
| — | NCT01064245 | Feb 2010 → Dec 2021 | cough variant asthma | Dr. Diane Lougheed | Completed | No outcome recorded |
| — | NCT00550758 | May 2004 → Apr 2007 | asthma | Rambam Health Care Campus | Terminated | No outcome recorded |
Also used as a comparator or background therapy in 7 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 44 trials | ||||||
| Phase 4 | NCT03105843 Background | Mar 2022 → Jun 2026 overdue | cough variant asthma | Dr. Diane Lougheed | Recruiting | No outcome recorded |
| Phase 4 | NCT02574975 Comparator | Apr 2015 → May 2016 | asthma | Zhujiang Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT01907334 Comparator | Aug 2013 → May 2014 | asthma | University of Florida | Completed | No outcome recorded |
| Phase 4 | NCT01642745 Comparator | Nov 2011 → Feb 2013 | asthma | University of Saskatchewan | Completed | No outcome recorded |
| Phase not applicable3 trials | ||||||
| — | NCT01699594 Comparator | Oct 2012 → May 2014 | allergic asthma | University of Saskatchewan | Completed | No outcome recorded |
| — | NCT01919424 Comparator | Apr 2011 → Oct 2013 | asthma | McMaster University | Completed | No outcome recorded |
| — | NCT00145990 Background | Sep → Dec 2005 | asthma | University of Florida | Completed | No outcome recorded |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 18 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Methacholine | “inhalation of triple-concentration increments (0.06 to13.9mg/ml/methacholine)” NCT00550758 ↗ |
| Known as | Chlorure de methacholine | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | Cloruro de metacolina | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | Mecholyl bromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | METHACHOLINE BROMIDE | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | Methacholine cation | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | Methacholine Chloride | “Drug: Methacholine Chloride” NCT01919424 ↗ |
| Known as | Methacholine ion | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | NSC-757090 | ChEMBL registry synonym — accepted as the source's own label CHEMBL978 ↗ |
| Known as | Provocholine | “Methacholine (Provocholine)” NCT01642745 ↗ |
| Known as | SK-1211 | “Methacholine Chloride (SK-1211)” NCT02100267 ↗1“Methacholine Chloride (SK-1211)” NCT02097537 ↗ |
| Action | Activate | “acts as a non-selective muscarinic receptor agonist” NCT01919424 ↗1“Muscarinic acetylcholine receptor M3 agonist” CHEMBL978 ↗ |
| Modality | Diagnostic / imaging agent | “methacholine challenge test performed in children previously diagnosed with asthma” NCT00550758 ↗ |
| Route | Inhaled | “inhaling methacholine through a nebulizer” NCT00145990 ↗ |
| Target | CHRM3 | “Muscarinic acetylcholine receptor M3 agonist” CHEMBL978 ↗ |