Drugs / UC-MSCs
last change Jul 2026 re-read 3 minutes ago

UC-MSCs

Cell therapy

Developed for
COVID-19 · cirrhosis of liver · acute respiratory distress syndrome · osteoarthritis, knee · psoriasis · alcoholic liver cirrhosis · allergic rhinitis · Alzheimer disease
+14 more · bronchopulmonary dysplasia · chronic ulcer of skin · Crohn disease · diabetic kidney disease · disease related to hematopoietic stem cell transplant · erectile dysfunction · liver failure · metabolic syndrome X · pneumonia · polycystic ovary syndrome · rheumatoid arthritis · systemic lupus erythematosus · type 1 diabetes mellitus · viral pneumonia
Investigated by
Beijing 302 Hospital · Vcanbio Cell and Gene Engineering Corp., Ltd. · Chinese PLA General Hospital · Renmin Hospital of Wuhan University · Shanghai Changzheng Hospital · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
+45 more · Wuhan Hamilton Bio-technology Co., Ltd · Joshua M Hare · LanZhou University · Puren Hospital Affiliated to Wuhan University of Science and Technology · South China Research Center for Stem Cell and Regenerative Medicine · Third Affiliated Hospital, Sun Yat-Sen University · Yantai Yuhuangding Hospital · Affiliated Hospital to Academy of Military Medical Sciences · COR clinic of Regenerative Medicine · Canadian Institutes of Health Research (CIHR) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Changhai Hospital · China Medical University Hospital · Chinese Academy of Medical Sciences · Fuzhou General Hospital · Galilee CBR · Guangzhou General Hospital of Guangzhou Military Command · Guangzhou Hamilton Biotechnology Co., Ltd. · Guangzhou Panyu Central Hospital · Hainan General Hospital · Huoshenshan Hospital · Jin Yin-tan Hospital · Jinnah Hospital · Johns Hopkins University · LiveKidney.Bio · Maternal and Child Health Hospital of Hubei Province · Medical University of South Carolina · Ottawa Hospital Research Institute · PT. Prodia Stem Cell Indonesia · Qingdao Co-orient Watson Biotechnology group co. LTD · Shaanxi Provincial People's Hospital · Shanghai East Hospital · Shanghai University · Sir Run Run Shaw Hospital · Southwest Hospital, China · The General Hospital of Central Theater Command · The Marcus Foundation · Tianjin Ever Union Biotechnology Co., Ltd. · Tuohua Biological Technology Co. Ltd · Vinmec Research Institute of Stem Cell and Gene Technology · Wuhan Hamilton Bio-technology Co., Ltd, China. · Wuhan Optics Valley Zhongyuan Pharmaceutical Co., Ltd., Hubei, China · Xijing Hospital · Xinjiang Kashi Area Number 1 Hospital · ZhiYong Peng

Trials 33

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 19 trials
Phase 1 NCT06737380 Jan 2025 → Jun 2026 overdue systemic lupus erythematosus LiveKidney.Bio Recruiting No outcome recorded
Phase 1 NCT06463847 Jun → Oct 2024 overdue osteoarthritis, knee Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting No outcome recorded
Phase 1 NCT04490486 Oct 2022 → Jun 2024 COVID-19, acute respiratory distress syndrome Joshua M Hare Withdrawn No outcome recorded Stop: Business
Phase 1 NCT05151133 Jun 2022 → Dec 2024 allergic rhinitis Yantai Yuhuangding Hospital Unknown No outcome recorded
Phase 1 NCT05155657 Jun 2022 → Dec 2024 alcoholic liver cirrhosis Yantai Yuhuangding Hospital Unknown No outcome recorded
Phase 1 NCT05331872 Jan 2021 → Sep 2023 cirrhosis of liver Vinmec Research Institute of Stem Cell and Gene Technology Completed No outcome recorded
Phase 1 NCT03424629 Jun → Sep 2018 psoriasis Tianjin Ever Union Biotechnology Co., Ltd. Unknown No outcome recorded
Phase 1 NCT02685722 Jan 2012 → Dec 2015 chronic ulcer of skin Chinese PLA General Hospital Completed No outcome recorded
Phase 1 NCT01207869 Jul 2010 → Jun 2012 bronchopulmonary dysplasia China Medical University Hospital Unknown No outcome recorded
Phase 1/210 trials
Phase 1/2 NCT06550752 Aug → Oct 2024 overdue erectile dysfunction COR clinic of Regenerative Medicine Not yet recruiting No outcome recorded
Phase 1/2 NCT05279768 Sep 2022 → Jan 2025 polycystic ovary syndrome PT. Prodia Stem Cell Indonesia Completed No outcome recorded
Phase 1/2 NCT05507762 Jul 2021 → Jul 2023 cirrhosis of liver Renmin Hospital of Wuhan University Unknown No outcome recorded
Phase 1/2 NCT04339660 Feb → Jun 2020 COVID-19 Puren Hospital Affiliated to Wuhan University of Science and Technology Unknown No outcome recorded
Phase 1/2 NCT03059355 Apr 2018 → Mar 2020 metabolic syndrome X Joshua M Hare Terminated No outcome recorded Stop: Business
Phase 1/2 NCT02672306 Oct 2017 → Oct 2018 Alzheimer disease South China Research Center for Stem Cell and Regenerative Medicine Unknown No outcome recorded
Phase 1/2 NCT02815423 Jan 2017 → Jan 2019 — South China Research Center for Stem Cell and Regenerative Medicine Unknown No outcome recorded
Phase 1/2 NCT02491658 Apr 2015 → Dec 2016 psoriasis Affiliated Hospital to Academy of Military Medical Sciences Unknown No outcome recorded
Phase 1/2 NCT02445547 Jun 2012 → Jun 2015 Crohn disease Fuzhou General Hospital Completed No outcome recorded
Phase 1/2 NCT01218464 Mar 2009 → Mar 2014 liver failure Beijing 302 Hospital Unknown No outcome recorded
Phase 27 trials · 1 missed
Phase 2 NCT07547735 Mar 2025 → May 2027 expected osteoarthritis, knee Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting No outcome recorded
Phase 2 NCT05224960 Jun 2024 → Jun 2025 overdue cirrhosis of liver Beijing 302 Hospital Recruiting No outcome recorded
Phase 2 NCT05121870 Sep 2021 → Jun 2023 cirrhosis of liver Beijing 302 Hospital Unknown No outcome recorded
Phase 2 NCT04865107 Apr 2021 → Apr 2022 COVID-19, acute respiratory distress syndrome Ottawa Hospital Research Institute Completed No outcome recorded
Phase 2 NCT04437823 Jun 2020 → Oct 2021 COVID-19 Jinnah Hospital Completed No outcome recorded
Phase 2 NCT04288102 Mar → May 2020 COVID-19 Beijing 302 Hospital Completed Missed primary
Phase 2 NCT04269525 Feb → Dec 2020 viral pneumonia ZhiYong Peng Unknown No outcome recorded
Phase 31 trial
Phase 3 NCT05689008 Jan → Mar 2023 pneumonia Shanghai East Hospital Unknown No outcome recorded
Phase 41 trial
Phase 4 NCT02218437 Oct 2013 → Oct 2015 disease related to hematopoietic stem cell transplant Chinese Academy of Medical Sciences Unknown No outcome recorded
Phase not applicable5 trials
— NCT06407297 May 2024 → Sep 2025 type 1 diabetes mellitus Shanghai Changzheng Hospital Unknown No outcome recorded
— NCT04562025 Sep 2020 → Sep 2021 diabetic kidney disease Renmin Hospital of Wuhan University Unknown No outcome recorded
— NCT04273646 Apr → Jun 2020 COVID-19 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Unknown No outcome recorded
— NCT04293692 Feb 2020 COVID-19 Puren Hospital Affiliated to Wuhan University of Science and Technology Withdrawn No outcome recorded
— NCT03798028 Dec 2017 → Dec 2019 rheumatoid arthritis Xijing Hospital Unknown No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 34 sources stand behind the page.

FieldValueCited text
Known as UC-MSCs “In mesenchymal stem cells (MSC) group, UC-MSCs were injected intravenously at a dose of 1 × 106/kg per week starting on the 14th day after administration of rabbit...” PMID 33639900 ↗ Feb 2021
32

“Umbilical cord-derived mesenchymal stem cells (UCMSCs) have been shown to repair damaged liver, kidney, heart, pancreas, skin, cartilage, and cornea in animal models and...” NCT04437823 ↗

“This is a phase I, open label, single arm trial using UC-MSCs to treat patients with liver cirrhosis” NCT05331872 ↗

“In this study, UC-MSCs were used to treat patients with hormone-controlled Crohn's disease.” NCT02445547 ↗

“human umbilical cord mesenchymal stem cells (UC-MSCs) via peripheral vein transfusion” NCT01218464 ↗

NCT05224960 ↗

NCT05121870 ↗

NCT06407297 ↗

NCT05507762 ↗

NCT05689008 ↗

NCT04269525 ↗

Show 22 more sources

Known as human umbilical cord mesenchymal stem cells “Human umbilical cord mesenchymal stem cells (UC-MSCs), as the "youngest" adult stem cells, have powerful anti-inflammatory functions, stronger differentiation potential, and...” NCT04562025 ↗
6

“The present clinical trial is to explore the safety and efficacy of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) therapy for novel coronavirus pneumonia patients.” NCT04293692 ↗

“We performed a phase 2 trial to assess the efficacy and safety of human umbilical cord-mesenchymal stem cells (UC-MSCs) to treat severe COVID-19 patients with lung damage.” PMID 33568628 ↗ Feb 2021

“Clinical Study of Moderate to Severe Persistent Allergic Rhinitis Therapy by Human Umbilical Cord Mesenchymal Stem Cells” NCT05151133 ↗

“Human Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) therapy” NCT04273646 ↗

“human umbilical cord mesenchymal stem cells (UC-MSCs)” NCT01218464 ↗

“Human Umbilical Cord-Mesenchymal Stem Cells (UC-MSCs)” NCT05121870 ↗

Known as human umbilical cord MSC “human umbilical cord MSC (UC-MSCs) treatment for patients with LF.” NCT01218464 ↗
Known as Human Umbilical Cord-derived Mesenchymal Stem Cells “Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis” NCT05121870 ↗
Known as human umbilical cord-derived MSCs “Compared with MSCs from other sources, human umbilical cord-derived MSCs (UC-MSCs) have been widely applied to various diseases due to their convenient collection, no ethical...” NCT04293692 ↗
Known as MSC “In mesenchymal stem cells (MSC) group, UC-MSCs were injected intravenously at a dose of 1 × 106/kg per week starting on the 14th day after administration of rabbit...” PMID 33639900 ↗ Feb 2021
Known as MSCs “allogeneic, umbilical cord-derived (UC) mesenchymal stromal cells (MSCs)” NCT04865107 ↗
Known as Umbilical Cord Mesenchymal Stem Cell “Umbilical Cord Mesenchymal Stem Cell (UC-MSCs)” NCT05279768 ↗
Known as Umbilical cord Mesenchymal Stem Cells “Umbilical Cord Mesenchymal Stem Cells Between Gel Treatment Difficult Skin Ulcer Healing Efficacy and Safety of Random, Open, Before-and-after Study” NCT02685722 ↗
4

“Thus far, the use of umbilical cord mesenchymal stem cells (UC-MSCs) to treat Crohn's disease has rarely been reported.” NCT02445547 ↗

“Umbilical cord Mesenchymal Stem Cells (UCMSCs) in the treatment of Allergic rhinitis (AR)” NCT05151133 ↗

“umbilical cord mesenchymal stem cells (UCMSCs)” NCT05155657 ↗

“umbilical cord mesenchymal stem cells” NCT05689008 ↗

Known as Umbilical Cord Tissue Derived Mesenchymal Stem Cells (UCMSCs) “Umbilical Cord Tissue Derived Mesenchymal Stem Cells (UCMSCs) administered intravenously in patients with acute pulmonary inflammation due to COVID-19” NCT04490486 ↗
Known as umbilical cord-derive mesenchymal stem cells “Recent clinical trials demonstrate that bone marrow-derived stem cells (BMDSCs) as well as umbilical cord-derive mesenchymal stem cells (UC-MSCs) improve liver function in...” NCT05331872 ↗
Known as umbilical cord-derived mesenchymal stem cells “Umbilical cord-derived mesenchymal stem cells (UCMSCs) have been shown to repair damaged liver, kidney, heart, pancreas, skin, cartilage, and cornea in animal models and...” NCT04437823 ↗
Known as umbilical cord-derived MSCs “umbilical cord-derived MSCs (ucMSCs) is safe and effective as a rescue treatment for severe BPD.” NCT01207869 ↗
Action Restore “have the ability to regenerate and repair damaged tissue” NCT06550752 ↗
Modality Cell therapy “Mesenchymal stem cells (MSCs)” NCT01207869 ↗
Route Other “will be instilled through a 6 French end-hole catheter inserted into the infant's endotracheal tube” NCT01207869 ↗