Drugs / L-asparaginase
last change Jun 2026 re-read 3 minutes ago

L-asparaginase

also known as Asparaginase · L-ASA · Erwinase · ERYASPASE · Kidrolase · SPECTRILA

Protein / enzyme biologic

Developed for
acute lymphoblastic leukemia · lymphoblastic lymphoma · T-cell non-Hodgkin lymphoma · extranodal nasal NK/T cell lymphoma · mature T-cell and NK-cell non-Hodgkin lymphoma · CD4+/CD56+ hematodermic neoplasm · childhood acute lymphoblastic leukemia · lymphoma
+2 more · non-Hodgkin lymphoma · acute myeloid leukemia
Investigated by
St. Jude Children's Research Hospital · PETHEMA Foundation · National Cancer Institute (NCI) · Samsung Medical Center · The University of Hong Kong · Bristol-Myers Squibb
+30 more · Cancer Hospital of Guizhou Province · Centre Henri Becquerel · Centre Hospitalier Universitaire Dijon · Centre Hospitalier Universitaire de Besancon · Children's Hospital of Philadelphia · Chonnam National University Hospital · ERYtech Pharma · Fudan University · Ho Joon Im · Inserm CIC1431, CHU Besancon · Maisonneuve-Rosemont Hospital · Memorial Sloan Kettering Cancer Center · Mingzhi Zhang · National Cancer Centre, Singapore · National University Hospital, Singapore · Ortho Biotech, Inc. · Pusan National University Yangsan Hospital · Qingdao University · Second Hospital of Shanxi Medical University · Seoul National University Hospital · Seoul St. Mary's Hospital · Severance Hospital · Shanxi Province Cancer Hospital · The First Affiliated Hospital of Henan University of Traditional Chinese Medicine · UMR1098, EFS BFC, BESANCON · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · University of Medicine and Dentistry of New Jersey · Wuhan TongJi Hospital · Wuhan University · Xinyang Central Hospital

Trials 21

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT04230330 Dec 2019 → Jun 2020 mature T-cell and NK-cell non-Hodgkin lymphoma National Cancer Centre, Singapore Withdrawn No outcome recorded
Phase 1 NCT01910428 Oct 2013 → Jan 2018 acute lymphoblastic leukemia, lymphoblastic lymphoma ERYtech Pharma Terminated No outcome recorded Stop: Business
Phase 26 trials
Phase 2 NCT05827549 Apr 2024 → Dec 2032 expected acute lymphoblastic leukemia Ho Joon Im Recruiting No outcome recorded
Phase 2 NCT03599960 May 2019 → Feb 2023 CD4+/CD56+ hematodermic neoplasm Centre Hospitalier Universitaire de Besancon Unknown No outcome recorded
Phase 2 NCT02544425 Feb 2016 → Aug 2021 mature T-cell and NK-cell non-Hodgkin lymphoma Samsung Medical Center Unknown No outcome recorded
Phase 2 NCT00854425 Jun 2008 → Jan 2012 lymphoma Fudan University Completed No outcome recorded
Phase 2 NCT00186875 Nov 2003 → Aug 2016 acute lymphoblastic leukemia, lymphoblastic lymphoma St. Jude Children's Research Hospital Completed No outcome recorded
Phase 2 NCT00610883 May 1990 → Dec 2008 non-Hodgkin lymphoma Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 33 trials
Phase 3 NCT03623087 Jul 2017 → Mar 2020 T-cell non-Hodgkin lymphoma, extranodal nasal NK/T cell lymphoma The University of Hong Kong Unknown No outcome recorded
Phase 3 NCT00137111 Jul 2000 → Nov 2010 acute lymphoblastic leukemia St. Jude Children's Research Hospital Completed No outcome recorded
Phase 3 NCT00187005 Jul 1998 → Jul 2002 acute lymphoblastic leukemia St. Jude Children's Research Hospital Terminated No outcome recorded
Phase 47 trials · 2 met primary
Phase 4 NCT03071822 Feb 2017 → Jul 2021 T-cell non-Hodgkin lymphoma The University of Hong Kong Unknown No outcome recorded
Phase 4 NCT01501149 Jan 2011 → Dec 2015 extranodal nasal NK/T cell lymphoma Mingzhi Zhang Unknown Met primary
Phase 4 NCT02894645 Oct 2008 → Oct 2018 childhood acute lymphoblastic leukemia National University Hospital, Singapore Unknown Met primary
Phase 4 NCT02036489 Jan 2008 → Dec 2019 acute lymphoblastic leukemia PETHEMA Foundation Completed No outcome recorded
Phase 4 NCT00526409 Jun 2005 → Oct 2014 acute lymphoblastic leukemia PETHEMA Foundation Completed No outcome recorded
Phase 4 NCT00526175 Jun 2001 → May 2015 acute lymphoblastic leukemia PETHEMA Foundation Completed No outcome recorded
Phase 4 NCT00526305 Jan 2000 → Apr 2005 acute lymphoblastic leukemia PETHEMA Foundation Completed No outcome recorded
Phase not applicable3 trials
— NCT00161239 Feb 2005 → Oct 2007 T-cell non-Hodgkin lymphoma University of Medicine and Dentistry of New Jersey Terminated No outcome recorded
— NCT00187057 Sep 2002 → Aug 2006 ataxia telangiectasia St. Jude Children's Research Hospital Completed No outcome recorded
— NCT00187122 Mar 1993 → Jun 2004 lymphoblastic lymphoma St. Jude Children's Research Hospital Completed No outcome recorded
Comparator or background therapy18 trials
Phase 1/2 NCT07585734 Background Apr 2025 → Apr 2026 T-cell acute lymphoblastic leukemia Institute of Hematology & Blood Diseases Hospital, China Withdrawn No outcome recorded
Phase 1/2 NCT03246750 Background Jan 2019 → Apr 2024 extranodal nasal NK/T cell lymphoma The Thai Lymphoma Study Group Completed No outcome recorded
Phase 1/2 NCT00098839 Background Feb 2005 → Apr 2011 childhood acute lymphoblastic leukemia Children's Oncology Group Completed No outcome recorded
Phase 2 NCT06099366 Background Mar 2024 → Dec 2033 expected childhood acute lymphoblastic leukemia Hee Young Ju Recruiting No outcome recorded
Phase 2 NCT04440267 Background Jul 2020 → Jun 2026 overdue acute leukemia of ambiguous lineage Institute of Hematology & Blood Diseases Hospital, China Recruiting No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 39 sources stand behind the page.

FieldValueCited text
Known as L-asparaginase “VDCLP regimen (vincristine, daunorubicin, cyclophosphamide, L-asparaginase, and prednisone) combined with CM313 at the RP2D during induction therapy.” NCT07585734 ↗
38

“L-asparaginase 10,000 units for square meter, intramuscular, days 6, 8, 10, 12, 14, 16, 19, 21, 23” NCT02451774 ↗

“SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy” PMID 35708709 ↗ Jul 2022

“fixed-dose MAD (Methotrexate, L-asparaginase and Dexamethasone) chemotherapy” NCT03246750 ↗

“L-asparaginase 6,000 IU/m2(days 2-4 start, total 9 doses for 3 weeks)” NCT05827549 ↗

“L-asparaginase (SPECTRILA) : 5000 units/m² IV at D2, 5, 8, 11” NCT03599960 ↗

“L-asparaginase (10 000 U/m2, i.m., weekly)” NCT03390387 ↗

“L-Asparaginase” NCT02665065 ↗

NCT00186875 ↗

NCT06336395 ↗

NCT00098839 ↗

Show 28 more sources

Known as Asparaginase “Asparaginase 10,000 U/m2/dose IM days 2, 4, 6, 8, 10, 12” NCT00187057 ↗
1

“ASPARAGINASE 20.000 u/m2 i.m. day 22” NCT00526409 ↗

Known as Erwinase “L - Asparaginase (Erwinase)” NCT03860844 ↗
Known as ERYASPASE “The investigational product ERYASPASE is a dispersion for infusion of homologous red blood cells (RBC) encapsulating E. coli L-asparaginase.” NCT01910428 ↗
Known as Kidrolase “L -asparaginase ( L -ASA ) of E. coli ( Kidrolase ® ) : 10,000 IU/m2 , iv , 16-20 , 23-27 .” NCT02036489 ↗
Known as L-ASA “L-asparaginase (L-ASA): 10.000 UI/m2, i.m. or i.v., days 9 to 11, 16 to 18 and 23 to 25.” NCT00526175 ↗
1

“L-asparaginase (L-ASA): 10.000 UI/m2, i.v.days 5-7 and 11-13” NCT00526305 ↗

Known as SPECTRILA “L-asparaginase (SPECTRILA) : 5000 units/m² IV at D2, 5, 8, 11” NCT03599960 ↗
Modality Protein / enzyme biologic “Native E.coli asparaginase” NCT01518517 ↗
Route Intramuscular “Given IM” NCT00098839 ↗