drugset / Trial / NCT00131027
High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to investigate the clinical efficacy of high-dose methotrexate consolidation therapy for adult patients with BCR-ABL-negative ALL.
Timeline
- Start
- 2002-09
- Primary completion
- 2011-03
- Completion
- 2011-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Methotrexate | Small molecule | 0.5 g | — |
| Comparator | Methotrexate | Small molecule | 3 g | — |
| Background | Cyclophosphamide | Other / unclassified | — | — |
| Background | Cytarabine | Small molecule | — | — |
| Background | Daunorubicin | Small molecule | — | — |
| Background | Dexamethasone | Small molecule | — | — |
| Background | Doxorubicin | Other / unclassified | — | — |
| Background | Etoposide | Small molecule | — | — |
| Background | MERCAPTOPURINE ANHYDROUS | Small molecule | — | — |
| Background | Prednisolone | Other / unclassified | — | — |
| Background | Vincristine | Small molecule | — | — |
| Background | asparaginase | Protein / enzyme biologic | — | — |